| Type | Description |
|---|---|
| Definition | NIMA (never in mitosis gene a)-related expressed kinase 8 |
| Date | Results | Publications |
|---|---|---|
| 2018-01-20 11:19:00 | We constructed sub-congenic lines to more specifically localize the modifier and have determined it resides in a 3.2 Mb interval containing 28 genes. These include Invs and Anks6, which are both excellent candidates for the modifier as mutations in these genes result in PKD and both genes are known to genetically and physically interact with Nek8. | 27114383 |
| 2017-06-24 10:40:00 | NEK8 plays a critical role in replication fork stability through its regulation of the DNA repair and replication fork protection protein RAD51. | 27892797 |
| 2013-03-09 10:24:00 | NEK8-depleted inner medullary collecting duct cells exhibited a defective response to fluid shear. | 23274954 |
| 2012-10-13 10:25:00 | Nek8 acts downstream of Inv function | 22687244 |
| 2010-05-10 12:01:00 | Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary cilia. | 20169535 |
| Type | IDs |
|---|---|
| Synonymous | 4632401F23Rik, b2b1449Clo, jck |
| Gene |
UniProtKB-ID:
NEK8_MOUSE
UniprotKB:
Q91ZR4
UniParc:
UPI00000E66E8
EMBL:
BC070457,
AF407579,
AK154358
Ensembl:
ENSMUSG00000017405
KO:
mmu:140859
|
| Nucleutide sequences |
EMBL-CDS:
BAE32535.1,
AAH70457.1,
AAL09675.1
Ensembl_TRS:
ENSMUST00000017549
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000017549
RefSeq:
XP_006532248.1,
XP_006532247.1,
XP_006532246.1,
NP_543125.1
|
| Others |
UniRef100:
UniRef100_Q91ZR4
UniRef90:
UniRef90_Q91ZR4
UniRef50:
UniRef50_Q86SG6
UniGene:
Mm.23788
CCDS:
CCDS25091.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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