Wdr5 - WD repeat domain 5-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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140858 Wdr5

基因描述

Type	Description
Definition	WD repeat domain 5

研究结论

Date	Results	Publications
2020-03-28 10:46:00	Our results show that an enrichment of activating histone marks at the Runx2/p57 P1 promoter is accompanied by the simultaneous interaction of Wdr5 and Utx proteins in differentiating MC3T3 mouse osteoblasts	30256410
2017-12-02 11:16:00	Cbx8 associates with non-PRC1 complexes containing the H3K4 methyltransferase complex component WDR5, which together regulate Notch gene expression.	27346354
2016-06-28 11:17:00	Wdr5 suppression also reduced IFNgamma, Il-1beta, and TNFalpha induced chemokine gene expression in b-cells without affecting islet-cell survival or b-cell function after 48hrs, but did begin to increase islet-cell apoptosis	26505193
2015-11-21 10:44:00	results suggest that specific RNAs are integral inputs into the WDR5-MLL complex for maintenance of the active chromatin state and embryonic stem cell fates	24521543
2015-08-01 11:47:00	Data show that broad association of myc proto-oncogene protein MYC with chromatin depends on interaction with the WD40-repeat protein WDR5.	25818646

名称对应

Type	IDs
Synonymous	2410008O07Rik, AA408785, AA960360, Big, Big-3
Gene	UniProtKB-ID: WDR5_MOUSE UniprotKB: P61965 UniParc: UPI00000040F5 EMBL: BC008547, AK075937, BC025801, AF416510, BC016103 Ensembl: ENSMUSG00000026917 KO: mmu:140858
Nucleutide sequences	EMBL-CDS: AAH25801.1, AAH16103.1, AAL27006.1, AAH08547.1, BAC36067.1 Ensembl_TRS: ENSMUST00000113952
Protein sequencees	Ensembl_PRO: ENSMUSP00000109585 RefSeq: XP_006497735.1, NP_543124.1
Others	UniRef100: UniRef100_P61964 UniRef90: UniRef90_P61964 UniRef50: UniRef50_P61964 UniGene: Mm.28265 CCDS: CCDS15829.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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全选

Pubmed编号	文献信息	发表日期	相关基因
32325033	BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Cell Syst Reza Pourhaghighi , Peter E A Ash , Sadhna Phanse , Florian Goebels , Lucas Z M Hu , Siwei Chen , Yingying Zhang , Shayne D Wierbowski , Samantha Boudeau , Mohamed T Moutaoufik , Ramy H Malty , Edyta Malolepsza , Kalliopi Tsafou , Aparna Nathan , Graham Cromar , Hongbo Guo , Ali Al Abdullatif , Daniel J Apicco , Lindsay A Becker , Aaron D Gitler , Stefan M Pulst , Ahmed Youssef , Ryan Hekman , Pierre C Havugimana , Carl A White , Benjamin C Blum , Antonia Ratti , Camron D Bryant , John Parkinson , Kasper Lage , Mohan Babu , Haiyuan Yu , Gary D Bader , Benjamin Wolozin , Andrew Emili	2020-04-22	-
32098917	Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. J Biosci Avinash Srivastava , Rakesh K Mishra	2020-01-01	-
31138677	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. J. Cell. Sci. Richa Das , Lukas Schwintzer , Stanislav Vinopal , Eva Aguado Roca , Marc Sylvester , Ana-Maria Oprisoreanu , Susanne Schoch , Frank Bradke , Meike Broemer	2019-06-17	-
30256410	Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts. J Cell Physiol Adriana Rojas , Hugo Sepulveda , Berta Henriquez , Rodrigo Aguilar , Tatiana Opazo , Gino Nardocci , Fernando Bustos , Jane B Lian , Janet L Stein , Gary S Stein , Brigitte van Zundert , Andre J van Wijnen , Miguel L Allende , Martin Montecino	2019-05-01	-
27661449	Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis. Elife Chintan K Kikani , Xiaoying Wu , Litty Paul , Hana Sabic , Zuolian Shen , Arvind Shakya , Alexandra Keefe , Claudio Villanueva , Gabrielle Kardon , Barbara Graves , Dean Tantin , Jared Rutter	2016-09-23	-
27346354	Cbx8 Acts Non-canonically with Wdr5 to Promote Mammary Tumorigenesis. Cell Rep Chi-Yeh Chung , Zhen Sun , Gavriel Mullokandov , Almudena Bosch , Zulekha A Qadeer , Esma Cihan , Zachary Rapp , Ramon Parsons , Julio A Aguirre-Ghiso , Eduardo F Farias , Brian D Brown , Alexandre Gaspar-Maia , Emily Bernstein	2016-07-12	-
26584622	Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Genes Dev. Paulina A Latos , Arnold R Sienerth , Alexander Murray , Claire E Senner , Masanaga Muto , Masahito Ikawa , David Oxley , Sarah Burge , Brian J Cox , Myriam Hemberger	2015-12-01	LOC100044627, Rpl5, LOC100862455, Rpl31, Ctnnd1, Cct2, Cct8, Smc3, Ddb1, Dhx9, Elf5, Eomes, Igf2bp1, Wdr5, Hspa5, Hcfc1, Hira, Hspa9, Ilf3, Eif6, Kpna2, Matr3, Mbd3, Mki67, Map1b, Myef2, Myo5a, Ints6, Orc1, Pa2g4, Pnn, Rfc1, Rpl10a, Rpl19, Rpl26, Rpl27, Rpl28, Rpl30, Rpl37a, Rpl9, Polr2a, Rps15, Sart1, Scin, Sin3a, Snrpc, Snrpb, Bptf, Zfp143, Ints9, Tfap2c, Top1, Top2b, Tuba1c, Ubp1, Pphln1, Yy1, Zfp281, Emsy, Grhl2, Esrrb, Rpl23a, Gtf3c4, Rpl13, Rpl7a, Rpl3, Gtse1, Iqgap1, Igf2bp2, Chd7, L1td1, Hist1h1c, Suz12, Rplp1, Prpf40a, Rbm14, Akap8, Snd1, Hic2, Rpl23, Rpl15, Snrnp40, Rbm25, Rpl14, Eif2s2, Rpl4, Hnrnpul2, Flnc, Vwa9, Zcchc8, Ints10, Asun, Skiv2l2, Zmym2, Zc3h18, Rpl18a, Ints7, Ehmt1, Zfp687
26180087	MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet Î²-Cell Function. Diabetes David W Scoville , Holly A Cyphert , Lan Liao , Jianming Xu , Al Reynolds , Shuangli Guo , Roland Stein	2015-11-01	-
26496610	A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell Marco Y Hein , Nina C Hubner , Ina Poser , JÃ¼rgen Cox , Nagarjuna Nagaraj , Yusuke Toyoda , Igor A Gak , Ina Weisswange , JÃ¶rg Mansfeld , Frank Buchholz , Anthony A Hyman , Matthias Mann	2015-10-22	Cep85l, Rcc1, Zbtb48, Bsdc1, Kifc1, Ccp110, Ints4, Slc6a8, Cenpi, Nup107, Xpo1, Fbxw11, Tubg1, Csnk1d, Bap1, Ptpn23, Tecpr2, Slain1, Ankrd28, Prkaa1, Espl1, Gbf1, Cdc20, Cenpf, Trip11, Mbd5, Kif22, Dut, Srsf1, Actb, Spred2, Akt2, Mta1, Tgs1, Pip4k2c, Ankfy1, Apc, Ar, Rhoa, Atp2a2, Atp5a1, Atp7a, Cep131, Bach1, Bcl7c, Bmpr1a, Brca1, Bub1, Bub1b, C1qbp, Anxa2, Calu, Cbx1, Cbx4, Cct2, Cct3, Cct4, Cct7, Cct8, Cd2ap, Cdk1, Cdc37, Cdh1, Chek1, Cit, Copa, Crebbp, Cry1, Csk, Smc3, Dctn1, Ddb1, Cdk2ap1, Mapre1, Ect2, Eef1a1, Eif3a, Mark2, Evpl, Ewsr1, Wdr5, Dclre1b, Fbl, Fgfr1, Flot1, Flot2, B4galt1, Gnb1, Gspt1, Hdac6, Herc2, Hsf1, Hsph1, Elavl1, Id2, Cyr61, Cep250, Insr, Eif3e
26365490	Systematic identification of factors for provirus silencing in embryonic stem cells. Cell Bin Xia Yang , Chadi A El Farran , Hong Chao Guo , Tao Yu , Hai Tong Fang , Hao Fei Wang , Sharon Schlesinger , Yu Fen Samantha Seah , Germaine Yen Lin Goh , Suat Peng Neo , Yinghui Li , Matthew C Lorincz , Vinay Tergaonkar , Tit-Meng Lim , Lingyi Chen , Jayantha Gunaratne , James J Collins , Stephen P Goff , George Q Daley , Hu Li , Frederic A Bard , Yuin-Han Loh	2015-09-24	Mdn1, Wdr92, Rtn1, Rcor2, Tsr1, Ankrd28, Chd4, Dnajc9, Cops8, Rcc2, Chaf1b, Aldoc, Mta1, Mta3, Brca1, Ctnna1, Cbx1, Cbx3, Cbx5, Cdh1, Eif3a, Smarcad1, Wdr5, Ppm1g, Trip12, Hdac2, Hspa8, Hsph1, Eif3e, Lig1, Mcm2, Mcm4, Mcm6, Mre11a, Msh2, Msh6, Ppp1r12a, Npm1, Npm3, Pcna, Ppp1ca, Prpf8, Rad50, Ranbp2, Rbbp4, Rfc1, Reps1, Rfc2, Ruvbl2, Sec23a, Cyfip1, Sin3a, Smarca4, Smarcc1, Eftud2, Sde2, Gps1, Tbl1x, Wdr18, Sbno2, Kat7, Timeless, Tjp2, Sec24c, Ulk1, Usp9x, Uxt, Eif3l, Prrc2c, Ikbkap, Nrd1, Ipo7, Gatad2a, Heatr3, Vac14, Rbbp7, Esrrb, Cops3, Cops5, Cops4, Cops6, Aifm1, Sec23b, Chaf1a, Trp53bp1, Eif3b, Hist1h3d, Hist1h4d, Snrnp200, Hdac1, Fbxo15, Nckap1, Ctps, Rif1, Ppp6r3, Cdc23, Eif3g, Ddx20, Eif3i

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