| Type | Description |
|---|---|
| Definition | sestrin 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-04-11 10:11:00 | Sestrins are critical mediators of exercise benefits. Genetic ablation of Sestrins prevents mice from acquiring metabolic benefits of exercise and improving their endurance through training. Sestrin upregulation mimics both molecular and physiological effects of exercise, suggesting that it is a major effector of exercise metabolism. AKT and PGC1alpha are critical for the Sestrin effects in extending endurance. | 31929512 |
| 2020-03-28 10:32:00 | By upregulating AMPK and autophagic activities and suppressing mammalian target of rapamycin complex 1 and oxidative stress, sestrins counteract detrimental effects of doxorubicin on cardiomyocytes. | 31026186 |
| 2018-02-24 10:12:00 | Sestrin 1 targets at the AMPK/mTORC1/autophagy pathway to inhibit cardiac hypertrophy by interaction with AMPK which is responsible for autophagy regulation. Taken together, our data indicate that Sestrin 1 regulates AMPK/mTORC1/autophagy axis to attenuate cardiac hypertrophy. | 28181410 |
| 2015-05-16 10:11:00 | Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK or TSC2. Surprisingly, when coexpressed with a GTP-bound constitutively active form of RagB (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids. | 25259925 |
| 2010-01-21 00:00:00 | Sestrin1 and Sestrin2 therefore provide an important link between genotoxic stress, p53 and the mTOR signaling pathway. | 18692468 |
| Type | IDs |
|---|---|
| Synonymous | 1110002G11Rik, AU044290, Pa26, Sest1 |
| Gene |
UniProtKB-ID:
SESN1_MOUSE,
E9PXR3_MOUSE,
Q497S6_MOUSE
UniprotKB:
P58006,
E9PXR3,
Q497S6
UniParc:
UPI0000574FCE,
UPI0000D8AFC2,
UPI00000251E1
EMBL:
AC115297,
BC055753,
AC165442,
BC100403
Ensembl:
ENSMUSG00000038332
KO:
mmu:140742
|
| Nucleutide sequences |
EMBL-CDS:
AAH55753.1,
AAI00404.1
Ensembl_TRS:
ENSMUST00000041438,
ENSMUST00000099931
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000043034,
ENSMUSP00000097515
RefSeq:
NP_001013388.2,
NP_001156380.1
|
| Others |
UniRef100:
UniRef100_Q497S6,
UniRef100_P58006,
UniRef100_E9PXR3
UniRef90:
UniRef90_Q9Y6P5,
UniRef90_Q9Y6P5-2
UniRef50:
UniRef50_P58004,
UniRef50_Q9Y6P5
UniGene:
Mm.139418
CCDS:
CCDS23809.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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