Gpr6 - G protein-coupled receptor 6-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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140741 Gpr6

基因描述

Type	Description
Definition	G protein-coupled receptor 6

研究结论

Date	Results	Publications
2014-08-16 10:49:00	Gpr6 deficiency causes an interesting behavioural phenotype in the form of enhanced motor activity combined with reduced abnormal involuntary movements.	24747358
2013-03-02 10:52:00	C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity	23150673
2010-01-21 00:00:00	identification, characterization and cloning; identified sphingosine-1-phosphate as a high-affinity ligand	14592418
2010-01-21 00:00:00	Gpr6 is the first striatopallidal neuron-specific genetic regulator of instrumental conditioning in a mammal.	17934457

名称对应

Type	IDs
Synonymous	AI852874, Gm233
Gene	UniProtKB-ID: GPR6_MOUSE UniprotKB: Q6YNI2 UniParc: UPI0000021747 EMBL: AK139367, AY064488 Ensembl: ENSMUSG00000046922 KO: mmu:140741
Nucleutide sequences	EMBL-CDS: AAL40876.1, BAE23977.1 Ensembl_TRS: ENSMUST00000061796
Protein sequencees	Ensembl_PRO: ENSMUSP00000057323 RefSeq: NP_951013.1
Others	UniRef100: UniRef100_Q6YNI2 UniRef90: UniRef90_Q6YNI2 UniRef50: UniRef50_Q6YNI2 UniGene: Mm.290693 CCDS: CCDS23802.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
32561725	Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nat Commun Clement Soleilhavoup , Marco Travaglio , Kieran Patrick , Pedro GarÃ§Ã£o , Elangovan Boobalan , Youri Adolfs , Ruth V Spriggs , Emma Moles-Garcia , Dalbir Dhiraj , Tony Oosterveen , Sarah L Ferri , Ted Abel , Edward S Brodkin , R Jeroen Pasterkamp , Brian P Brooks , Lia Panman	2020-06-19	-
29967281	SP8 and SP9 coordinately promote D2-type medium spiny neuron production by activating Six3 expression. Development Zhejun Xu , Qifei Liang , Xiaolei Song , Zhuangzhi Zhang , Susan Lindtner , Zhenmeiyu Li , Yan Wen , Guoping Liu , Teng Guo , Dashi Qi , Min Wang , Chunyang Wang , Hao Li , Yan You , Xin Wang , Bin Chen , Hua Feng , John L Rubenstein , Zhengang Yang	2018-07-23	-
28433741	Loss of the neurodevelopmental gene Zswim6 alters striatal morphology and motor regulation. Neurobiol. Dis. David J Tischfield , Dave K Saraswat , Andrew Furash , Stephen C Fowler , Marc V Fuccillo , Stewart A Anderson	2017-07-01	-
27651149	Increased susceptibility of G-protein coupled receptor 6 deficient mice to MPTP neurotoxicity. Neuroscience Patrick Oeckl , Boris Ferger	2016-11-19	-
27452460	The Zinc Finger Transcription Factor Sp9 Is Required for the Development of Striatopallidal Projection Neurons. Cell Rep Qiangqiang Zhang , Yue Zhang , Chunyang Wang , Zhejun Xu , Qifei Liang , Lei An , Jiwen Li , Zhidong Liu , Yan You , Miao He , Ying Mao , Bin Chen , Zhi-Qi Xiong , John L Rubenstein , Zhengang Yang	2016-08-02	-
24952961	A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron Carol L Thompson , Lydia Ng , Vilas Menon , Salvador Martinez , Chang-Kyu Lee , Katie Glattfelder , Susan M Sunkin , Alex Henry , Christopher Lau , Chinh Dang , Raquel Garcia-Lopez , Almudena Martinez-Ferre , Ana Pombero , John L R Rubenstein , Wayne B Wakeman , John Hohmann , Nick Dee , Andrew J Sodt , Rob Young , Kimberly Smith , Thuc-Nghi Nguyen , Jolene Kidney , Leonard Kuan , Andreas Jeromin , Ajamete Kaykas , Jeremy Miller , Damon Page , Geri Orta , Amy Bernard , Zackery Riley , Simon Smith , Paul Wohnoutka , Michael J Hawrylycz , Luis Puelles , Allan R Jones	2014-07-16	-
24747358	G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease. Exp. Neurol. Patrick Oeckl , Bastian Hengerer , Boris Ferger	2014-07-01	Gpr6, Ppp1r1b
24351932	Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity. Proc. Natl. Acad. Sci. U.S.A. Kuan-Ming Lu , Sylvia M Evans , Shinji Hirano , Fu-Chin Liu	2014-01-07	Adora2a, Calb1, Calb2, Casp3, Chat, Chrm4, Drd1, Drd2, Ebf1, Gpr6, Isl1, Mef2c, Nos1, Oprm1, Pax6, Pcdh10, Pdyn, Penk, Pvalb, Tac1, Nkx2-1, Plxnd1, Slc35d3
23150673	C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-Î² neurotoxicity. J Biol Chem Marie E Benoit , Michael X Hernandez , Minhan L Dinh , Francisca Benavente , Osvaldo Vasquez , Andrea J Tenner	2013-01-04	-
23070814	The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Genes Dev. Lionel Budry , AurÃ©lio Balsalobre , Yves Gauthier , Konstantin Khetchoumian , Aurore L'honorÃ© , Sophie Vallette , Thierry Brue , Dominique Figarella-Branger , BjÃ¶rn Meij , Jacques Drouin	2012-10-15	Gpc5, Gldc, Steap4, Cdkn1b, Cdkn1c, Cebpd, Crhr1, Dll3, Drd2, Gpr6, Gcgr, Gh, Glp1r, Gpr50, Grik1, Hgf, Irgm1, Lhb, Mc3r, Mki67, Mx2, Neurod1, Pax7, Pcsk2, Pomc, Prl, Scn7a, Sox2, Tgtp1, Tshb, Alpk2, Avpr1b, Map3k8, Nr5a1, Fndc3c1, Rbfox3, Tbx19

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