| Type | Description |
|---|---|
| Definition | zinc finger and BTB domain containing 46 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-12 10:04:00 | ZBTB46 is inversely correlated with SPDEF and is increased in higher tumor grades and small-cell NE prostate cancer (SCNC) patients, which are positively associated with PTGS1. Findings suggest that the induction of ZBTB46 results in increased PTGS1 expression, which is associated with NEPC progression and linked to the dysregulation of the AR-SPDEF pathway. | 30312731 |
| 2019-08-17 11:41:00 | In vitro results using endothelial cells (ECs) showed that cell confluence and laminar shear stress, both known physiological conditions promoting EC quiescence, led to upregulation of ZBTB46 expression. | 29884909 |
| 2019-07-20 11:28:00 | ZBTB46 is able to clearly define the dendritic cell identity of many previously unclassified histiocytic disease subtypes. All examined cases of Langerhans cell histiocytosis and histiocytic sarcoma expressed ZBTB46, while all cases of blastic plasmacytoid dendritic cell neoplasm, chronic myelomonocytic leukemia, juvenile xanthogranuloma, Rosai-Dorfman disease, and Erdheim-Chester disease failed to express ZBTB46. | 29743654 |
| 2017-12-02 10:52:00 | Authors report a novel tumor promoter, ZBTB46, which is negatively regulated by AR signaling via microRNA (miR)-1-mediated downregulation. ZBTB46 is associated with malignant prostate cancer and is essential for metastasis. | 28692046 |
| 2013-08-10 11:44:00 | A single nucleotide polymorphisn in ZBTB46, rs6062314, is associated with an increased genetic risk for multiple sclerosis. | 23739915 |
| Type | IDs |
|---|---|
| Synonymous | BTBD4, BZEL, RINZF, ZNF340, dJ583P15.7, dJ583P15.8 |
| Gene |
UniProtKB-ID:
ZBT46_HUMAN,
Q6ZMU8_HUMAN,
A0A494BZW5_HUMAN
UniprotKB:
Q86UZ6,
Q6ZMU8,
A0A494BZW5
UniParc:
UPI0000206406,
UPI000035E7FE,
UPI0000420B09
EMBL:
CH471077,
BC052269,
AL121845,
AK131482,
BC073800,
AL158091
Ensembl:
ENSG00000130584
KO:
hsa:140685
|
| Nucleutide sequences |
EMBL-CDS:
EAW75205.1,
AAH52269.1,
EAW75206.1,
AAH73800.1,
BAD18627.1
Ensembl_TRS:
ENST00000395104,
ENST00000302995,
ENST00000245663,
ENST00000650966
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000378536,
ENSP00000303102,
ENSP00000245663,
ENSP00000498245
RefSeq:
XP_005260252.1,
XP_005260255.1,
XP_016883156.1,
NP_079500.2,
XP_005260254.1,
XP_006723763.1,
NP_001356670.1,
XP_011526850.1,
XP_011526851.1
|
| Others |
UniRef100:
UniRef100_Q6ZMU8,
UniRef100_A0A494BZW5,
UniRef100_Q86UZ6
UniRef90:
UniRef90_Q8BID6,
UniRef90_A0A494BZW5
UniRef50:
UniRef50_Q8BID6,
UniRef50_H0WHC0
UniGene:
Hs.585028
CCDS:
CCDS13538.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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