| Type | Description |
|---|---|
| Definition | engulfment and cell motility 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-07 12:13:00 | Platelet aggregation, granule secretion, integrin alphaIIbbeta3 activation, and thromboxane generation were enhanced in ELMO1(-/-) platelets in response to glycoprotein VI (GPVI) agonists but unaltered when a protease-activated receptor 4 agonist was used. These results indicate that ELMO1 plays an important role in hemostasis and thrombosis in vivo. | 30787021 |
| 2019-05-18 10:10:00 | ELMO1 protects against DSS-induced colonic injury in mice through its effect on epithelial migration via Rac1 activation. | 30219846 |
| 2019-05-11 13:02:00 | Loss of the engulfment signaling protein Elmo1 alleviated disease severity in mouse models of arthritis through Elmo1's regulation of neutrophil recruitment to inflamed joints. | 30643265 |
| 2019-03-30 10:25:00 | ELMO1 is present in the phagosome and enhances bacterial clearance by differential regulation of lysosomal acidification and enzymatic activity. | 29029244 |
| 2017-12-16 10:28:00 | The authors identify ELMO1 as a novel target of TGFbeta signaling and show that restoration of Tgfbr2 results in a complete block of ELMO1 in vivo. Knocking down Elmo1 impairs metastasis of carcinoma cells to the lung, thereby providing insights into the mechanisms of progression of Tgfbr2-deficient invasive transition zone squamous cell carcinoma. | 28219480 |
| Type | IDs |
|---|---|
| Synonymous | 6330578D22Rik, C230095H21Rik, CED-12 |
| Gene |
UniProtKB-ID:
ELMO1_MOUSE
UniprotKB:
Q8BPU7
UniParc:
UPI0000029896,
UPI00000EB027,
UPI0000006BEA,
UPI000019B4F7
EMBL:
BC031782,
AK053306,
AF398883,
AK028389,
BC024727
Ensembl:
ENSMUSG00000041112
KO:
mmu:140580
|
| Nucleutide sequences |
EMBL-CDS:
AAH24727.1,
AAH31782.1,
BAC35336.1,
AAL14464.1,
BAC25925.1
Ensembl_TRS:
ENSMUST00000072519,
ENSMUST00000180626
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000152595,
ENSMUSP00000072334
RefSeq:
XP_006516608.1,
XP_006516609.1,
NP_525027.1,
NP_932761.1,
XP_006516610.1,
XP_006516607.1,
XP_030103002.1,
XP_030103001.1
|
| Others |
UniRef100:
UniRef100_Q8BPU7
UniRef90:
UniRef90_Q92556
UniRef50:
UniRef50_Q92556
UniGene:
Mm.342392
CCDS:
CCDS26265.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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