| Type | Description |
|---|---|
| Definition | protein phosphatase 1, regulatory subunit 3A |
| Date | Results | Publications |
|---|---|---|
| 2019-07-06 13:00:00 | Mice lacking Ppp1r3a are protected against pressure-overload heart failure. Condition-specific cardiac regulatory gene networks identify disease-driven changes in local and global topology and pathway organization, illuminating Ppp1r3a as a novel predicted heart failure regulator. | 31235787 |
| 2010-01-21 00:00:00 | Mice in which human PPP1R3A C1984DeltaAG replaced mouse PP1R3A had decreased muscle glycogen levels because failure of the truncated mutant to bind glycogen & colocalize with glycogen synthase (GS) decreased GS & increased glycogen phosphorylase activity. | 18232732 |
| 2010-01-21 00:00:00 | results show that dysfunction of subunit PPP1R3A of protein phosphatase 1 leads to weight gain, increased fat deposition and insulin resistance | 12606498 |
| 2010-01-21 00:00:00 | Backcrossing of G(M)-/- mice onto two different genetic backgrounds gave rise to lean, glucose-tolerant, insulin-sensitive G(M)-/- mice indicating that at least one variant gene,is required for the development of the prediabetic phenotype of obese mice. | 18234908 |
| 2003-07-04 14:59:00 | Disruption of the Ppp1r3a gene does not result in either fat deposition or insulin resistance, but PPP1r3a is essential for control of glycogen metabolism by exercise. | 11283248 |
| Type | IDs |
|---|---|
| Synonymous | GM, RG1, RGL |
| Gene |
UniProtKB-ID:
PPR3A_MOUSE
UniprotKB:
Q99MR9
UniParc:
UPI0000025F48
EMBL:
AK084518,
AK084719,
AF309629,
BC109007,
AF309628,
CH466533
Ensembl:
ENSMUSG00000042717
KO:
mmu:140491
|
| Nucleutide sequences |
EMBL-CDS:
EDL13902.1,
AAK31072.1,
AAI09008.1,
BAC39262.2,
BAC39208.2
Ensembl_TRS:
ENSMUST00000045096
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000049054
RefSeq:
NP_536712.2
|
| Others |
UniRef100:
UniRef100_Q99MR9
UniRef90:
UniRef90_Q99MR9
UniRef50:
UniRef50_Q16821
UniGene:
Mm.209429
CCDS:
CCDS19917.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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