| Type | Description |
|---|---|
| Definition | exostoses (multiple) 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 12:40:00 | Using mouse embryonic stem cell-derived mosaic tissues with compartments that lack Exostosin1 and Exostosin2, or Glypican5, it has been shown that Shh accumulates around its source cells when they are surrounded by cells that have a mutated extracellular matrix. | 30977233 |
| 2017-10-14 13:09:00 | reactivating SHH signaling in mutant lungs rescued the tip dilation phenotype and attenuated FGF signaling. Importantly, the reduced SHH signaling activity did not appear to be caused by decreased Shh expression or protein stability; instead, biologically active form of SHH proteins were reduced in both the Ext1 mutant epithelium and surrounding wild type mesenchymal cells. | 28859094 |
| 2016-05-14 10:11:00 | crucial for outflow tract formation in distinct progenitor cells and modulates FGF signaling during early heart development | 26295701 |
| 2016-02-06 10:05:00 | Normal heparin sulfate levels and Ext1 activity in the stromal microenvironment and hematopoietic stem cells are required for the transplant engraftment following non-myeloablative conditioning. | 25976459 |
| 2015-10-10 11:26:00 | Heterozygous loss of function of EXT1 and EXT2 results in a decreased arteriolar endothelial glycocalyx but improved flow mediated vasodilation. | 25468659 |
| Type | IDs |
|---|---|
| Synonymous | AA409028 |
| Gene |
UniProtKB-ID:
EXT1_MOUSE,
Q3V1P4_MOUSE
UniprotKB:
P97464,
Q3V1P4
UniParc:
UPI00000241A1
EMBL:
AK132327,
X96639,
U78539,
BC004741
Ensembl:
ENSMUSG00000061731
KO:
mmu:14042
|
| Nucleutide sequences |
EMBL-CDS:
AAH04741.1,
CAA65443.1,
AAB41728.1,
BAE21106.1
Ensembl_TRS:
ENSMUST00000077273
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000076505
RefSeq:
NP_034292.2
|
| Others |
UniRef100:
UniRef100_P97464
UniRef90:
UniRef90_P97464
UniRef50:
UniRef50_P97464
UniGene:
Mm.309395
CCDS:
CCDS27466.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员