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13870 Ercc1

13870

Ercc1

excision repair cross-complementing rodent repair deficiency, complementation group 1

protein-coding

Mus musculus

基因描述

Type Description
Definition excision repair cross-complementing rodent repair deficiency, complementation group 1

研究结论

Date Results Publications
2021-04-13 10:13:00 Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1(d/-) mice. 33493548
2020-07-25 11:27:00 analyses indicate that XPF-ERCC1 has important functions outside of its central role in nucleotide excision repair and Fanconi anaemia crosslink repair which are required to prevent endogenous DNA damage; failure to resolve such damage leads to loss of tissue homeostasis in mice and humans 32271760
2019-10-05 11:40:00 ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation (LPO) implicates LPO-induced DNA damage 29860127
2018-10-27 10:42:00 chronic treatment of Ercc1(-/) mice with the mitochondrial-targeted radical scavenger XJB-5-131 attenuated oxidative DNA damage, senescence and age-related pathology. 29747066
2017-09-16 12:30:00 Dietary tryptophan restriction increased microbial diversity and made the gut microbiota composition of old Ercc1(-/Delta7) mice more similar to that of young WT mice. 27418353

名称对应

Type IDs
Synonymous Ercc-1
Gene
UniProtKB-ID: ERCC1_MOUSE, E9PUM0_MOUSE
UniprotKB: P07903, E9PUM0
UniParc: UPI0000020D60, UPI000173A780
EMBL: AK136733, X07414, X07413, AK088271, AC148988, BC011224, CH466639
Ensembl: ENSMUSG00000003549
KO: mmu:13870
Nucleutide sequences
EMBL-CDS: BAE23112.1, AAH11224.1, BAC40249.1, CAA30310.1, EDL23137.1
Ensembl_TRS: ENSMUST00000003645, ENSMUST00000160369
Protein sequencees
Ensembl_PRO: ENSMUSP00000003645, ENSMUSP00000125655
RefSeq: NP_031974.2, NP_001120796.1
Others
UniRef100: UniRef100_P07903, UniRef100_E9PUM0
UniRef90: UniRef90_P07903
UniRef50: UniRef50_P07903
UniGene: Mm.280913
CCDS: CCDS20898.1

全选

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