| Type | Description |
|---|---|
| Definition | epidermal growth factor receptor pathway substrate 8 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:32:00 | EPS8 regulates an NLRP3 inflammasome-independent caspase-1 activation pathway in monosodium urate crystal-treated RAW264.7 macrophages. | 32595041 |
| 2019-04-13 11:08:00 | Scrutinized the motility of Hnrnpab(-/-) cells and confirmed that the decreases in both cell motility and Eps8 are restored by ectopically coexpressing both alternatively spliced Hnrnpab isoforms, therefore these variants are surprisingly nonredundant for cell motility. | 30314980 |
| 2017-07-22 10:17:00 | Absence of Eps8 produces a weaker phenotype in vestibular hair cells compared to cochlear inner hair cells, since it affects the hair bundle morphology but not the basolateral membrane currents. This difference is likely to explain the absence of obvious vestibular dysfunction in Eps8 knockout mice. | 27132230 |
| 2017-07-15 10:11:00 | Results implicate N-methyl-d-aspartate receptor hyperfunction in the cognitive deficits observed in Epidermal growth factor receptor substrate 8 (Eps8) knockout mice and demonstrate a novel role for Eps8 in regulating hippocampal long-term synaptic plasticity and cognitive function. | 27450093 |
| 2016-05-21 11:02:00 | These findings demonstrate a novel role for Wnt-Dvl1 signalling through Eps8 in the regulation of axonal remodeling. | 26252776 |
| Type | IDs |
|---|---|
| Synonymous | AW261790 |
| Gene |
UniProtKB-ID:
EPS8_MOUSE,
Q3U2Z5_MOUSE,
Q3UFL4_MOUSE
UniprotKB:
Q08509,
Q3U2Z5,
Q3UFL4
UniParc:
UPI00005AC7DD,
UPI00001F457F,
UPI00001F4585
EMBL:
AK148424,
BC016890,
AK155022,
L21671,
AK149683,
AK166156
Ensembl:
ENSMUSG00000015766
KO:
mmu:13860
|
| Nucleutide sequences |
EMBL-CDS:
AAH16890.1,
BAE29023.1,
BAE38601.1,
AAA16358.1,
BAE32995.1,
BAE28546.1
Ensembl_TRS:
ENSMUST00000058210,
ENSMUST00000100841,
ENSMUST00000111878
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000052776,
ENSMUSP00000098402,
ENSMUSP00000107509
RefSeq:
NP_001258524.1,
XP_030111005.1,
NP_001258518.1,
NP_031971.2,
XP_011239506.1,
NP_001258516.1,
NP_001258517.1,
XP_006505571.1
|
| Others |
UniRef100:
UniRef100_Q08509,
UniRef100_Q3UFL4
UniRef90:
UniRef90_Q3UFL4,
UniRef90_Q08509
UniRef50:
UniRef50_Q3UFL4,
UniRef50_Q08509
UniGene:
Mm.235346,
Mm.412332
CCDS:
CCDS20665.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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