| Type | Description |
|---|---|
| Definition | Eph receptor A3 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-22 15:27:00 | EPHA3 enhances macrophage autophagy and apoptosis by disrupting the mTOR signaling pathway in mice with endometriosis. | 31262977 |
| 2020-02-15 13:26:00 | In conclusion, PS1/gamma-secretase-dependent EphA3 cleavage mediates axon growth by regulating filament assembly through RhoA signaling and non-muscle myosin IIA (NMIIA), suggesting opposite roles of EphA3 on inhibiting (ligand-dependent) and promoting (receptor processing) axon growth in developing neurons. | 31577226 |
| 2018-10-20 12:08:00 | Although EPHA3 was reported to be one of the most frequently mutated genes in colorectal tumors, our studies using inducible isogenic cell line systems, mouse models and large human tumor collections, did not reveal a major role of this EPH receptor on proliferation/motility/invasion of cancer cells, tumor initiation/progression/metastasis in mouse models or survival of colorectal cancer patients. | 28169277 |
| 2017-06-03 12:15:00 | study delineates a mechanism in which NCAM promotes ephrin-A5-dependent clustering of EphA3 through interaction of the NCAM Ig2 domain and the EphA3 CRD, stimulating EphA3 autophosphorylation and RhoA signaling necessary for growth cone repulsion in GABAergic interneurons in vitro, which may extend to remodeling of axonal terminals of interneurons in vivo. | 27803162 |
| 2016-04-09 11:26:00 | Ephrin-A3 has a role in promoting and maintaining slow muscle fiber identity during postnatal development and reinnervation | 26644518 |
| Type | IDs |
|---|---|
| Synonymous | AW492086, Cek4, EK4, ETK1, End3, Hek, Hek4, Mek4, Tyro4 |
| Gene |
UniProtKB-ID:
Q8BRB1_MOUSE
UniprotKB:
Q8BRB1
UniParc:
UPI0000022049
EMBL:
AC154844,
BC138641,
AC154568,
AK045219,
AC155275,
AK132335,
BC138643
Ensembl:
ENSMUSG00000052504
|
| Nucleutide sequences |
EMBL-CDS:
BAC32266.1,
BAE21112.1,
AAI38644.1,
AAI38642.1
Ensembl_TRS:
ENSMUST00000064405
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000066554
RefSeq:
NP_034270.1,
NP_001349381.1
|
| Others |
UniRef100:
UniRef100_Q8BRB1
UniRef90:
UniRef90_P29320
UniRef50:
UniRef50_P29320
UniGene:
Mm.1977
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员