| Type | Description |
|---|---|
| Definition | eukaryotic translation initiation factor 4E binding protein 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:59:00 | 4E-BP1 Protects Neurons from Misfolded Protein Stress and Parkinson's Disease Toxicity by Inducing the Mitochondrial Unfolded Protein Response. | 33046555 |
| 2021-01-16 15:54:00 | Diabetes enhances translation of Cd40 mRNA in murine retinal Muller glia via a 4E-BP1/2-dependent mechanism. | 32475820 |
| 2020-08-22 15:30:00 | Inhibition of 4E-BP1 phosphorylation promotes tubular cell escaping from G2/M arrest and ameliorates kidney fibrosis. | 31154001 |
| 2020-06-27 12:26:00 | 4E-BP1 and 4E-BP2 contributes to the maintenance of muscle mass and function in aging through increased protein synthesis. Through metabolomic and global lipid analysis, study demonstrated that 4E-BPs play a role in the control of energy and amino acid metabolism in the skeletal muscle of 24-month-old mice. Thus, 4E-BPs may be potential drug targets in the treatment of sarcopenia. | 30927336 |
| 2019-10-19 11:01:00 | The retina of diabetic WT mice exhibited increased reactive oxygen species levels, an effect not observed in diabetic 4E-BP1/2-deficient mice. These findings provide evidence for a mechanism whereby diabetes-induced O-GlcNAcylation promotes oxidative stress in the retina by altering the selection of mRNAs for translation. | 30733333 |
| Type | IDs |
|---|---|
| Synonymous | 4e-bp1, AA959816, PHAS-I |
| Gene |
UniProtKB-ID:
4EBP1_MOUSE
UniprotKB:
Q60876
UniParc:
UPI00000237BD
EMBL:
U28656,
AK013033,
BC002045,
AK170031,
AK169979
Ensembl:
ENSMUSG00000031490
KO:
mmu:13685
|
| Nucleutide sequences |
EMBL-CDS:
AAA88818.1,
BAE41494.1,
AAH02045.1,
BAB28612.1,
BAE41521.1
Ensembl_TRS:
ENSMUST00000033880
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000033880
RefSeq:
NP_031944.3
|
| Others |
UniRef100:
UniRef100_Q60876
UniRef90:
UniRef90_Q60876
UniRef50:
UniRef50_Q13541
UniGene:
Mm.6700
CCDS:
CCDS22214.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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