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1368 CPM

1368

CPM

carboxypeptidase M

protein-coding

Homo sapiens

基因描述

Type Description
Definition carboxypeptidase M

研究结论

Date Results Publications
2020-02-01 13:07:00 Our work shows for the first time that the interaction between CPM and kinin B1 receptor alters not only B1R pharmacology, but also modulates enzyme expression and activity. 31218444
2019-11-16 13:01:00 The rs12812500 variant of the CPM gene may increase silicosis susceptibility by affecting the expression of CPM, which may contribute to silicosis susceptibility with biological plausibility. 30674606
2017-10-14 10:33:00 Low CPM expression is associated with colorectal cancer. 28186967
2014-01-25 11:19:00 CPM binding to extracellular loop 2 of the B1R results in positive allosteric modulation of B1R signaling, and disruption of this interaction could provide a novel therapeutic approach to reduce pathological B1R signaling. 24108126
2013-04-20 12:01:00 Carboxypeptidase M expression is lost in human renal cell carcinoma tumor cells, whereas it is abundant in tumor-associated foam cells and neovasculature. 23172796

名称对应

Type IDs
Gene
UniProtKB-ID: CBPM_HUMAN
UniprotKB: P14384
UniParc: UPI00001271D4
EMBL: AF262945, BC022276, AF262947, AF262943, AF262941, AK313180, AF262946, AF262942, AF262944, AF368463, AF262940, J04970
Ensembl: ENSG00000135678
KO: hsa:1368
Nucleutide sequences
EMBL-CDS: AAA35651.2, AAH22276.1, AAK69717.1, AAG47641.1, BAG35997.1
Ensembl_TRS: ENST00000551568, ENST00000338356, ENST00000546373
Protein sequencees
Ensembl_PRO: ENSP00000448517, ENSP00000447255, ENSP00000339157
RefSeq: NP_001005502.1, NP_001865.1, NP_938079.1
Others
UniRef100: UniRef100_P14384
UniRef90: UniRef90_P14384
UniRef50: UniRef50_P14384
UniGene: Hs.654387
CCDS: CCDS8987.1

全选

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研究热度

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