| Type | Description |
|---|---|
| Definition | leucine rich repeats and guanylate kinase domain containing |
| Date | Results | Publications |
|---|---|---|
| 2020-03-21 12:31:00 | The structure revealed that hGMPK consists of three distinct regions designated as the LID, GMP-binding (GMP-BD), and CORE domains and is in an open configuration that is nucleotide binding-competent. Nonsynonymous single-nucleotide variants of the hGMPK CORE domain distant from the nucleotide-binding site of this domain modulate enzymatic activity without significantly affecting hGMPK's structure. | 31201273 |
| 2015-12-19 12:03:00 | Study demonstrates that leucine-rich repeats and guanylate kinase-domain containing isoform 1 (LRGUK-1) is required for multiple aspects of sperm assembly, including acrosome attachment, sperm head shaping and the initiation of the axoneme growth to form the core of the sperm tail. | 25781171 |
| 2010-06-30 22:05:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| 2008-06-04 21:30:00 | Observational study of gene-disease association. (HuGE Navigator) | 18498660 |
| Type | IDs |
|---|---|
| Synonymous | CFAP246 |
| Gene |
UniProtKB-ID:
LRGUK_HUMAN
UniprotKB:
Q96M69
UniParc:
UPI0000072C76
EMBL:
AK057348,
BC104897,
CH471070,
CH236950,
BC104899
Ensembl:
ENSG00000155530
KO:
hsa:136332
|
| Nucleutide sequences |
EMBL-CDS:
AAI04898.1,
EAW83807.1,
BAB71441.1,
EAL24072.1,
AAI04900.1
Ensembl_TRS:
ENST00000285928
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000285928
RefSeq:
XP_024302426.1,
XP_024302431.1,
NP_001352630.1,
NP_001352629.1,
XP_024302427.1,
XP_024302428.1,
NP_653249.1,
XP_024302430.1,
XP_016867238.1,
XP_024302429.1
|
| Others |
UniRef100:
UniRef100_Q96M69
UniRef90:
UniRef90_Q96M69
UniRef50:
UniRef50_Q96M69
UniGene:
Hs.149774
CCDS:
CCDS5830.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32296183 |
A reference map of the human binary protein interactome. Nature Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat TaÅan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood |
2020-04-01 | - |
| 31201273 |
J Biol Chem Nazimuddin Khan , Parag P Shah , David Ban , Pablo Trigo-Mouriño , Marta G Carneiro , Lynn DeLeeuw , William L Dean , John O Trent , Levi J Beverly , Manfred Konrad , Donghan Lee , T Michael Sabo |
2019-08-02 | - |
| 25781171 |
LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility. PLoS Genet Yan Liu , Kathleen DeBoer , David M de Kretser , Liza O'Donnell , Anne E O'Connor , D Jo Merriner , Hidenobu Okuda , Belinda Whittle , David A Jans , Athina Efthymiadis , Robert I McLachlan , Christopher J Ormandy , Chris C Goodnow , Duangporn Jamsai , Moira K O'Bryan |
2015-03-01 | - |
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 20379614 |
Mol. Med. Jed E Rose , Frédérique M Behm , Tomas Drgon , Catherine Johnson , George R Uhl |
2010-03-17 | - |
| 18498660 |
BMC Med. Genet. Jason M Laramie , Jemma B Wilk , Sally L Williamson , Michael W Nagle , Jeanne C Latourelle , Jennifer E Tobin , Michael A Province , Ingrid B Borecki , Richard H Myers |
2008-01-01 |
LRGUK,
EXOC4
|
| 14702039 |
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. Toshio Ota , Yutaka Suzuki , Tetsuo Nishikawa , Tetsuji Otsuki , Tomoyasu Sugiyama , Ryotaro Irie , Ai Wakamatsu , Koji Hayashi , Hiroyuki Sato , Keiichi Nagai , Kouichi Kimura , Hiroshi Makita , Mitsuo Sekine , Masaya Obayashi , Tatsunari Nishi , Toshikazu Shibahara , Toshihiro Tanaka , Shizuko Ishii , Jun-ichi Yamamoto , Kaoru Saito , Yuri Kawai , Yuko Isono , Yoshitaka Nakamura , Kenji Nagahari , Katsuhiko Murakami , Tomohiro Yasuda , Takao Iwayanagi , Masako Wagatsuma , Akiko Shiratori , Hiroaki Sudo , Takehiko Hosoiri , Yoshiko Kaku , Hiroyo Kodaira , Hiroshi Kondo , Masanori Sugawara , Makiko Takahashi , Katsuhiro Kanda , Takahide Yokoi , Takako Furuya , Emiko Kikkawa , Yuhi Omura , Kumi Abe , Kumiko Kamihara , Naoko Katsuta , Kazuomi Sato , Machiko Tanikawa , Makoto Yamazaki , Ken Ninomiya , Tadashi Ishibashi , Hiromichi Yamashita , Katsuji Murakawa , Kiyoshi Fujimori , Hiroyuki Tanai , Manabu Kimata , Motoji Watanabe , Susumu Hiraoka , Yoshiyuki Chiba , Shinichi Ishida , Yukio Ono , Sumiyo Takiguchi , Susumu Watanabe , Makoto Yosida , Tomoko Hotuta , Junko Kusano , Keiichi Kanehori , Asako Takahashi-Fujii , Hiroto Hara , Tomo-o Tanase , Yoshiko Nomura , Sakae Togiya , Fukuyo Komai , Reiko Hara , Kazuha Takeuchi , Miho Arita , Nobuyuki Imose , Kaoru Musashino , Hisatsugu Yuuki , Atsushi Oshima , Naokazu Sasaki , Satoshi Aotsuka , Yoko Yoshikawa , Hiroshi Matsunawa , Tatsuo Ichihara , Namiko Shiohata , Sanae Sano , Shogo Moriya , Hiroko Momiyama , Noriko Satoh , Sachiko Takami , Yuko Terashima , Osamu Suzuki , Satoshi Nakagawa , Akihiro Senoh , Hiroshi Mizoguchi , Yoshihiro Goto , Fumio Shimizu , Hirokazu Wakebe , Haretsugu Hishigaki , Takeshi Watanabe , Akio Sugiyama , Makoto Takemoto , Bunsei Kawakami , Masaaki Yamazaki , Koji Watanabe , Ayako Kumagai , Shoko Itakura , Yasuhito Fukuzumi , Yoshifumi Fujimori , Megumi Komiyama , Hiroyuki Tashiro , Akira Tanigami , Tsutomu Fujiwara , Toshihide Ono , Katsue Yamada , Yuka Fujii , Kouichi Ozaki , Maasa Hirao , Yoshihiro Ohmori , Ayako Kawabata , Takeshi Hikiji , Naoko Kobatake , Hiromi Inagaki , Yasuko Ikema , Sachiko Okamoto , Rie Okitani , Takuma Kawakami , Saori Noguchi , Tomoko Itoh , Keiko Shigeta , Tadashi Senba , Kyoka Matsumura , Yoshie Nakajima , Takae Mizuno , Misato Morinaga , Masahide Sasaki , Takushi Togashi , Masaaki Oyama , Hiroko Hata , Manabu Watanabe , Takami Komatsu , Junko Mizushima-Sugano , Tadashi Satoh , Yuko Shirai , Yukiko Takahashi , Kiyomi Nakagawa , Koji Okumura , Takahiro Nagase , Nobuo Nomura , Hisashi Kikuchi , Yasuhiko Masuho , Riu Yamashita , Kenta Nakai , Tetsushi Yada , Yusuke Nakamura , Osamu Ohara , Takao Isogai , Sumio Sugano |
2004-01-01 |
Slc9a8,
Nefm,
Hfe2,
AKT3,
ZBTB11-AS1,
LOC100034248,
PDZK1P1,
DDTL,
LOC100049716,
ACOT8,
GNPDA1,
ZBTB33,
GTF2IP4,
POM121C,
ZSCAN30,
SRA1,
SNORD123,
UCKL1-AS1,
ZGLP1,
LOC100125918,
LINC00322,
LOC100127940,
HECW1-IT1,
LOC100127955,
LOC100127972,
LOC100127974,
FAM229A,
LOC100128076,
STAU2-AS1,
LOC100128164,
TMPO-AS1,
LOC100128219,
LOC100128239,
LOC100128253,
TNK2-AS1,
DNM1P35,
LOC100128288,
DLG5-AS1,
LOC100128310,
TRAPPC3L,
FAM83H-AS1,
LOC100128361,
LOC100128364,
FAM225B,
LOC100128386,
LOC100128398,
ASTN2-AS1,
C1orf132,
MYHAS,
LOC100128651,
LINC00476,
SRRM2-AS1,
GPR158-AS1,
LINC01165,
VPS9D1-AS1,
FAM66B,
GATA6-AS1,
LINC01310,
LOC100128979,
LOC100128988,
LOC100129034,
SEMA3F-AS1,
UNQ6494,
LOC100129115,
KHDC1L,
LOC100129175,
MATN1-AS1,
SLC39A12-AS1,
LOC100129297,
LOC100129312,
LINC00484,
LOC100129397,
LOC100129406,
DDC-AS1,
LOC100129434,
LOC100129447,
LOC100129455,
LYRM4-AS1,
ZNF37BP,
LOC100129516,
LOC100129518,
LOC100129540,
LOC100129572,
FAM47E,
LOC100129620,
LOC100129648,
C9orf173-AS1,
LOC100129775,
SLC25A21-AS1,
PCOLCE-AS1,
SCOC-AS1,
LOC100129884,
LOC100129894,
LOC100129917,
LOC100129935,
LOC100130078,
LOC100130111,
MAPT-IT1,
MIR124-2HG
|
| 12690205 |
Human chromosome 7: DNA sequence and biology. Science Stephen W Scherer , Joseph Cheung , Jeffrey R MacDonald , Lucy R Osborne , Kazuhiko Nakabayashi , Jo-Anne Herbrick , Andrew R Carson , Layla Parker-Katiraee , Jennifer Skaug , Razi Khaja , Junjun Zhang , Alexander K Hudek , Martin Li , May Haddad , Gavin E Duggan , Bridget A Fernandez , Emiko Kanematsu , Simone Gentles , Constantine C Christopoulos , Sanaa Choufani , Dorota Kwasnicka , Xiangqun H Zheng , Zhongwu Lai , Deborah Nusskern , Qing Zhang , Zhiping Gu , Fu Lu , Susan Zeesman , Malgorzata J Nowaczyk , Ikuko Teshima , David Chitayat , Cheryl Shuman , Rosanna Weksberg , Elaine H Zackai , Theresa A Grebe , Sarah R Cox , Susan J Kirkpatrick , Nazneen Rahman , Jan M Friedman , Henry H Q Heng , Pier Giuseppe Pelicci , Francesco Lo-Coco , Elena Belloni , Lisa G Shaffer , Barbara Pober , Cynthia C Morton , James F Gusella , Gail A P Bruns , Bruce R Korf , Bradley J Quade , Azra H Ligon , Heather Ferguson , Anne W Higgins , Natalia T Leach , Steven R Herrick , Emmanuelle Lemyre , Chantal G Farra , Hyung-Goo Kim , Anne M Summers , Karen W Gripp , Wendy Roberts , Peter Szatmari , Elizabeth J T Winsor , Karl-Heinz Grzeschik , Ahmed Teebi , Berge A Minassian , Juha Kere , Lluis Armengol , Miguel Angel Pujana , Xavier Estivill , Michael D Wilson , Ben F Koop , Sabrina Tosi , Gudrun E Moore , Andrew P Boright , Eitan Zlotorynski , Batsheva Kerem , Peter M Kroisel , Erwin Petek , David G Oscier , Sarah J Mould , Hartmut Döhner , Konstanze Döhner , Johanna M Rommens , John B Vincent , J Craig Venter , Peter W Li , Richard J Mural , Mark D Adams , Lap-Chee Tsui |
2003-05-02 |
BET1P1,
LOC100129603,
TUBB3P2,
C7orf72,
LOC100131859,
LOC100286906,
HSPA8P8,
LOC100287825,
DNAJB6,
LINC01006,
LOC100506557,
TMEM178B,
ABCF2,
ARPC1B,
ARL4A,
NAMPT,
AKAP9,
AASS,
LOC101927181,
CDK5,
CDK6,
POP7,
RAMP3,
LOC102724434,
BET1,
IKZF1,
SEMA3A,
NOD1,
GPNMB,
SEMA3C,
AGR2,
ARPC1A,
IGF2BP3,
YKT6,
ADCY1,
CFTR,
FGL2,
CPSF4,
FASTK,
COPS6,
KDELR2,
DUS4L,
NUPL2,
HIBADH,
ZNF277,
CHN2,
TP53TG1,
CHRM2,
GLCCI1,
FKBP9,
CBX3,
ZBED6CL,
TSGA13,
GPR146,
MALSU1,
AGAP3,
ADCYAP1R1,
CLK2P1,
C7orf13,
OR9A4,
CPA1,
C7orf34,
TMEM139,
OR2F2,
SSU72P8,
PRSS37,
KLF14,
SSMEM1,
MTPN,
LRGUK,
ASB10,
PRSS58,
MPLKIP,
ASZ1,
CRHR2,
RUNDC3B,
LINC00689,
KCTD7,
C7orf66,
GIMAP8,
CRYGN,
ZNF425,
CYP3A7,
AMZ1,
RBM33,
AGR3,
CYP3A4,
CYP3A5,
CYP51A1,
DGKB,
DDC,
AEBP1,
GALNTL5,
RNF133,
THAP5,
CCDC71L,
GIMAP7,
BHLHA15,
BMPER
|
| 12477932 |
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. Robert L Strausberg , Elise A Feingold , Lynette H Grouse , Jeffery G Derge , Richard D Klausner , Francis S Collins , Lukas Wagner , Carolyn M Shenmen , Gregory D Schuler , Stephen F Altschul , Barry Zeeberg , Kenneth H Buetow , Carl F Schaefer , Narayan K Bhat , Ralph F Hopkins , Heather Jordan , Troy Moore , Steve I Max , Jun Wang , Florence Hsieh , Luda Diatchenko , Kate Marusina , Andrew A Farmer , Gerald M Rubin , Ling Hong , Mark Stapleton , M Bento Soares , Maria F Bonaldo , Tom L Casavant , Todd E Scheetz , Michael J Brownstein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Christa Prange , Sam S Raha , Naomi A Loquellano , Garrick J Peters , Rick D Abramson , Sara J Mullahy , Stephanie A Bosak , Paul J McEwan , Kevin J McKernan , Joel A Malek , Preethi H Gunaratne , Stephen Richards , Kim C Worley , Sarah Hale , Angela M Garcia , Laura J Gay , Stephen W Hulyk , Debbie K Villalon , Donna M Muzny , Erica J Sodergren , Xiuhua Lu , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madan , Alice C Young , Yuriy Shevchenko , Gerard G Bouffard , Robert W Blakesley , Jeffrey W Touchman , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Martin I Krzywinski , Ursula Skalska , Duane E Smailus , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Marco A Marra , Mammalian Gene Collection Program Team |
2002-12-24 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员