| Type | Description |
|---|---|
| Definition | eukaryotic elongation factor-2 kinase |
| Date | Results | Publications |
|---|---|---|
| 2018-03-10 11:49:00 | This study provides new insights into the control of eEF2K by AMPK. | 28502587 |
| 2017-09-23 10:29:00 | eEF2K activity is increased in postmortem Alzheimer's disease (AD) patient cortex and hippocampus, and in the hippocampus of aged transgenic AD mice. eEF2K inhibition using pharmacological or genetic approaches prevented the toxic effects of Abeta42 oligomers on neuronal viability and dendrite formation in vitro. Findings highlight the potential utility of eEF2K inhibition to reduce Abeta-mediated oxidative stress in AD. | 27752775 |
| 2017-05-20 10:37:00 | results suggest that protective versus pro-apoptotic roles of eEF2K depend on the type of cells: eEF2K is protective in highly proliferative cells, such as small intestinal stem cells and cancer cells, which are more susceptible to mitotic catastrophe. | 27466362 |
| 2017-04-29 10:51:00 | Using an eEF2K gain-of-function design in vitro as well as eEF2K-KO mice, we show that eEF2K activity regulates the excitation/inhibition balance by downregulating vesicle release at inhibitory synapses and tonic inhibition. This translates into a reduced susceptibility of eEF2K-KO mice for seizures without major behavioral alterations with the exception of impaired contextual and trace fear memory | 27005990 |
| 2016-12-17 12:10:00 | hese data suggest that mmu-miR-125b decreases NO production in activated macrophages at least partially by suppressing eEF2K and CCNA2 expression. | 27020049 |
| Type | IDs |
|---|---|
| Synonymous | C86191, eEF-2K |
| Gene |
UniProtKB-ID:
EF2K_MOUSE,
Q8CEC8_MOUSE,
Q7TPC7_MOUSE,
Q8BNP6_MOUSE
UniprotKB:
O08796,
Q8CEC8,
Q7TPC7,
Q8BNP6
UniParc:
UPI00000E9146,
UPI00000EB19C,
UPI00001B508A,
UPI0000001847
EMBL:
BC055361,
BC003433,
U93848,
AK028524,
AK080915
Ensembl:
ENSMUSG00000035064
KO:
mmu:13631
|
| Nucleutide sequences |
EMBL-CDS:
AAH03433.1,
AAB58271.1,
BAC25990.1,
AAH55361.1,
BAC38076.1
Ensembl_TRS:
ENSMUST00000106488,
ENSMUST00000047875,
ENSMUST00000106489
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000102098,
ENSMUSP00000046595,
ENSMUSP00000102097
RefSeq:
NP_001254639.1,
XP_006507405.1,
XP_006507408.1,
NP_031934.1,
XP_006507407.1,
NP_001254640.1,
XP_036008548.1,
XP_006507406.1
|
| Others |
UniRef100:
UniRef100_Q8CEC8,
UniRef100_O08796,
UniRef100_Q7TPC7,
UniRef100_Q8BNP6
UniRef90:
UniRef90_P70531
UniRef50:
UniRef50_O00418
UniGene:
Mm.25997,
Mm.470116
CCDS:
CCDS21796.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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