| Type | Description |
|---|---|
| Definition | left right determination factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-10-10 12:58:00 | Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-beta/Smad signaling pathway. | 32065356 |
| 2018-09-22 11:29:00 | A cell that experiences the highest level of Nodal signaling begins to express Lefty1 and becomes an L1(epi) cell. Deletion of Lefty1 alone or together with Lefty2 increased the number of prospective DVE cells | 29138408 |
| 2018-08-04 10:51:00 | Lefty1 may ameliorate renal tubulointerstitial inflammation by suppressing NFkappaB signaling. | 29286065 |
| 2017-03-25 11:46:00 | results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A and DNMT3B; findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation and demethylation crucial to regulation of key signalling pathways in early body plan formation | 27760115 |
| 2016-10-08 10:03:00 | exogenous lefty1 administered to mice restored the endogenous expression levels of lefty1. The present study demonstrated that lefty1 attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 signaling pathway | 26647776 |
| Type | IDs |
|---|---|
| Synonymous | AI450052, Ebaf, Leftb, Stra3, Tgfb4, lefty, lefty-1 |
| Gene |
UniProtKB-ID:
LFTY1_MOUSE
UniprotKB:
Q64280
UniParc:
UPI0000024301
EMBL:
AJ000083,
BC050221,
AK131943,
AJ000082,
D83921,
Z73151
Ensembl:
ENSMUSG00000038793
KO:
mmu:13590
|
| Nucleutide sequences |
EMBL-CDS:
BAE20889.1,
CAA03910.1,
BAA12121.1,
CAA97497.1,
AAH50221.1,
CAA03909.1
Ensembl_TRS:
ENSMUST00000037361
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000041427
RefSeq:
NP_034224.1
|
| Others |
UniRef100:
UniRef100_Q64280
UniRef90:
UniRef90_Q64280
UniRef50:
UniRef50_Q64280
UniGene:
Mm.378911
CCDS:
CCDS15577.1
|