| Type | Description |
|---|---|
| Definition | tripartite motif containing 50 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-09 11:53:00 | TRIM50 acted as a tumor suppressor in hepatocarcinoma cells by directly targeting SNAIL and reversing epithelial-to-mesenchymal transition. | 29789583 |
| 2018-07-14 10:40:00 | TRIM50, via the RING domain, ubiquitinates Beclin 1 in a K63-dependent manner enhancing its binding with ULK1 and autophagy activity. | 29604308 |
| 2014-08-23 12:01:00 | TRIM50 K372 residue competes for post-translational protein modifications such as acetylation and ubiquitination. | 24308962 |
| 2013-04-06 10:45:00 | When the proteasome activity is impaired, TRIM50 fails to drive its substrates to the proteasome-mediated degradation. | 22792322 |
| 2010-01-21 00:00:00 | Encodes an E3 ubiquitin ligase; putatively involved in phenotype determination of Williams-Beuren syndrome. | 18398435 |
| Type | IDs |
|---|---|
| Synonymous | TRIM50A |
| Gene |
UniProtKB-ID:
TRI50_HUMAN,
Q2M204_HUMAN,
B7ZLG2_HUMAN
UniprotKB:
Q86XT4,
Q2M204,
B7ZLG2
UniParc:
UPI000015FD8F,
UPI0000D46857,
UPI0000684286,
UPI000017DA62
EMBL:
CH471200,
AK292074,
BC143787,
BC112152,
AC073841,
AY081949,
BC112154,
AY081948
Ensembl:
ENSG00000146755
KO:
hsa:135892
|
| Nucleutide sequences |
EMBL-CDS:
AAL91071.1,
AAL91072.1,
AAI12155.1,
AAI12153.1,
EAW69691.1,
EAW69688.1,
BAF84763.1,
AAI43788.1,
EAW69689.1
Gene_ORFName:
hCG_1642804,
hCG_1642804
Ensembl_TRS:
ENST00000453152,
ENST00000333149
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000413875,
ENSP00000327994
RefSeq:
XP_011514089.1,
NP_835226.2,
NP_001268379.1,
NP_001268380.1,
XP_011514091.2,
XP_011514090.1
|
| Others |
UniRef100:
UniRef100_Q2M204,
UniRef100_B7ZLG2,
UniRef100_Q86XT4
UniRef90:
UniRef90_Q86XT4
UniRef50:
UniRef50_Q86XT4
UniGene:
Hs.647053
CCDS:
CCDS34654.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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