Ear2 - eosinophil-associated, ribonuclease A family, member 2-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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13587 Ear2

基因描述

Type	Description
Definition	eosinophil-associated, ribonuclease A family, member 2

研究结论

Date	Results	Publications
2017-05-13 21:58:00	Functional activity of four mouse eosinophil associated ribonucleases, mEAR2, mEAR5, mEAR7 and mEAR11.	27765572
2014-08-23 12:15:00	Testing spatial memory and hippocampal long-term potentiation revealed an impairment in APP/PS1 Ear2(-/-) mice, whereas APP/PS1 or Ear2(-/-) mice showed only minor changes.	24966384
2013-09-07 10:47:00	this suggests that ECP can activate a canonical Wnt/b-catenin signaling pathway by enhancing the stabilization of b-catenin during cardiomyocyte differentiation.	23271121
2011-05-21 11:23:00	Ear2 ligand binding domain is required for Rasd1 to alleviate Ear2-mediated repression of renin transcription.	21247419
2010-01-21 00:00:00	EDN can activate myeloid DCs by triggering the Toll-like receptor (TLR)2-myeloid differentiation factor 88 signaling pathway	18195069

名称对应

Type	IDs
Synonymous	EAR-13, EAR-2, ECP, ECP 2, Raf3, Rnase2
Gene	UniProtKB-ID: ECP2_MOUSE, W0UVF7_MOUSE UniprotKB: P97425, W0UVF7 UniParc: UPI0000000A73 EMBL: HG328947, BC065391, U72031, AF306665, AF306664, BC094626 Ensembl: ENSMUSG00000072596 KO: mmu:13587
Nucleutide sequences	EMBL-CDS: AAB37785.1, AAG25991.1, AAG25992.1, AAH94626.1, AAH65391.1, CDG32023.1 Ensembl_TRS: ENSMUST00000074839
Protein sequencees	Ensembl_PRO: ENSMUSP00000074386 RefSeq: NP_031921.1
Others	UniRef100: UniRef100_P97425 UniRef90: UniRef90_P97425 UniRef50: UniRef50_O35291 UniGene: Mm.327386 CCDS: CCDS26968.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
27765572	Mouse eosinophil associated ribonucleases: Mechanism of cytotoxic, antibacterial and antiparasitic activities. Int. J. Biol. Macromol. Ayush Attery , Janendra K Batra	2017-01-01	-
26147683	The transcription factor XBP1 is selectively required for eosinophil differentiation. Nat. Immunol. Sarah E Bettigole , Raphael Lis , Stanley Adoro , Ann-Hwee Lee , Lisa A Spencer , Peter F Weller , Laurie H Glimcher	2015-08-01	Xbp1
24966384	Ear2 deletion causes early memory and learning deficits in APP/PS1 mice. J. Neurosci. Markus P Kummer , Thea Hammerschmidt , Ana Martinez , Dick Terwel , Gregor Eichele , Anika Witten , Stefanie Figura , Monika Stoll , Stephanie Schwartz , Hans-Christian Pape , Joachim L Schultze , David Weinshenker , Michael T Heneka , Inga Urban	2014-06-25	Ear2, Nr2f6
24337645	Comparative genomic analysis of eutherian ribonuclease A genes. Mol. Genet. Genomics Marko Premzl	2014-04-01	Ang2, Ear1, Ear2, Ang4, Rnase9, Rnase12, Rnase11, Rnase2b, Rnase4, Rnase10, Ear10, LOC100361814, Ear1, Rnase10, Rnase12, Rnase1l1, Rnase2, Ang2, Rnase11, Rnase4, LOC100714967, Rnase13, Rnase6, LOC100716938, Rnase12, Rnase11, Rnase10, LOC102526782, RNASE12, RNASE10, RAC3, RNASE1, Rnase13, RAB3, RAB6, RAA1, RAA2, RNASE11, RAB8, LOC102422773, RAB7, RAA3, LOC102436641, LOC102440480, RAM1, RAB1, RAB2, LOC100586798, RAM2, RNASE6, RNASE1, RNASE10, LOC100597969, RNASE7, RNASE9, LOC101179261, RNASE6, RNASE9, RNASE7, RNASE6, RAE1, ANG, EDDM3A, RNASE1, RNASE3, RNASE10, RNASE6, RNASE7, RNASE8, RNASE12, LOC100425237, RNASE3, RNASE10, RNASE11, RNASE12, RNASE4, EDDM3B, RNASE6, RNASE1, RNASE2, RAI1, RAM1, RNASE3, RNASE7, RNASE7, RNASE1, RNASE10, ANG, EDDM3A, EDDM3B, RNASE4, RNASE13, RNASE9, RNASE10, EDDM3A, RNASE6, EDDM3B, RNASE3, EDDM3A
23271121	Eosinophil cationic protein enhances stabilization of Î²-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells. Mol. Biol. Rep. Guoliang Jin , Akifumi Mizutani , Takayuki Fukuda , Takayuki Otani , Ting Yan , Marta Prieto Vila , Hiroshi Murakami , Takayuki Kudoh , Satoshi Hirohata , Tomonari Kasai , David S Salomon , Masaharu Seno	2013-04-01	-
21873635	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas	2011-09-01	-
21247419	Rasd1 interacts with Ear2 (Nr2f6) to regulate renin transcription. BMC Mol Biol Jen Jen Tan , Shufen Angeline Ong , Ken-Shiung Chen	2011-01-19	-
18195069	Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. J. Exp. Med. De Yang , Qian Chen , Shao Bo Su , Ping Zhang , Kahori Kurosaka , Rachel R Caspi , Suzanne M Michalek , Helene F Rosenberg , Ning Zhang , Joost J Oppenheim	2008-01-21	Ear2, Myd88, Tlr1, Tlr6, Tlr2, MYD88, RNASE2, TLR2
16123981	Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform. Dev. Dyn. Murat Burak Yaylaoglu , Andrew Titmus , Axel Visel , Gonzalo Alvarez-Bolado , Christina Thaller , Gregor Eichele	2005-10-01	Dscr3, Ear2, Nr2f6, Fgf1, Fgf10, Fgf11, Fgf12, Fgf13, Fgf14, Fgf15, Fgf17, Fgf18, Fgf2, Fgf3, Fgf4, Fgf5, Fgf6, Fgf7, Fgf8, Fgf9, Fgfr1, Fgfr2, Fgfr3, Fgfr4, Trhde, Fgf21, Fgf23, Fgf22, Fgf20, Fgf16
15741322	Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception. Genes Dev. Marei Warnecke , Henrik Oster , Jean-Pierre Revelli , Gonzalo Alvarez-Bolado , Gregor Eichele	2005-03-01	Phox2a, Arntl, Atoh1, Dbh, Ear2, Egr2, Nr2f6, Hoxa1, Hoxb1, Ascl1, Npas2, Per1, Per2, Phox2b, Th, Prok2, Fam101b

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