| Type | Description |
|---|---|
| Definition | dopamine receptor D4 |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 11:10:00 | Our structure reveals a secondary binding pocket extended from the orthosteric ligand-binding pocket to a DRD4-specific crevice located between transmembrane helices 2 and 3. Additional mutagenesis studies suggest that the antagonist L745870 prevents DRD4 activation by blocking the relative movement between transmembrane helices 2 and 3 | 31750832 |
| 2020-03-14 12:22:00 | Male DRD4 KO mice failed to reinstate their preference after a priming dose following successful extinction. No differences in locomotor activity were observed within drug treatment conditions due to genotype, and female mice displayed reduced locomotor activity during CPP conditioning compared to male mice. | 30797855 |
| 2018-10-13 11:29:00 | data imply that enhanced D4 receptor-mediated dopaminergic control of corticostriatal transmission constitutes a vulnerability factor of ADHD and other neuropsychiatric disorders. | 28097219 |
| 2018-07-21 10:38:00 | Results indicate that the full rescue of impaired LTP in aging is achieved by the selective D4R activation. | 28975698 |
| 2018-03-03 10:11:00 | over-suppression of NMDAR function may underlie the role of hD4.7 in attention deficit hyperactivity disorder | 27475724 |
| Type | IDs |
|---|---|
| Synonymous | AW125663, D4R, Drd-4 |
| Gene |
UniProtKB-ID:
DRD4_MOUSE
UniprotKB:
P51436
UniParc:
UPI0000000E83
EMBL:
S80928,
CH466531,
S80927,
BC051421,
U19880,
AK044379,
S80920,
BC016086,
S80929
Ensembl:
ENSMUSG00000025496
KO:
mmu:13491
|
| Nucleutide sequences |
EMBL-CDS:
AAB50730.1,
EDL18041.1,
AAH16086.1,
AAH51421.2,
BAC31893.1,
AAC52190.1
Ensembl_TRS:
ENSMUST00000026569
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000026569
RefSeq:
XP_006536219.1,
XP_017177461.1,
NP_031904.1
|
| Others |
UniRef100:
UniRef100_P51436
UniRef90:
UniRef90_P30729
UniRef50:
UniRef50_P30729
UniGene:
Mm.41075
CCDS:
CCDS22007.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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