| Type | Description |
|---|---|
| Definition | StAR related lipid transfer domain containing 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 12:37:00 | STARD4 has a conserved alpha-helix/beta-grip fold with a deep hydrophobic pocket.STARD4 binds sterol in the pocket and transport sterol between liposomes. Sterol binding requires a conformational change to form a complementary pocket. | 31607485 |
| 2020-07-18 11:28:00 | Knockdown of STARD4, a sterol transporter, leads to large changes in the lipidome. STARD4-KD cells also have large changes in their mRNA profile. There is an increase in cellular cholesterol, including in late endosomes. These results indicate that STARD4 plays important roles in lipid homeostasis. | 31917335 |
| 2017-06-03 10:20:00 | This study shows that nonvesicular sterol transport mechanisms and STARD4 in particular account for a large fraction of sterol transport between the plasma membrane and the ERC. | 28209730 |
| 2014-11-22 10:55:00 | Studies show the 3 steroidogenic acute regulatory-related lipid transfer (START) domain proteins StarD4, StarD5 and StarD6 have a similar lipid binding pocket specific for sterols (cholesterol in particular), but differing regulation and localization. | 24440759 |
| 2013-04-27 10:39:00 | The data indicate a role for STARD4 in nonvesicular transport of cholesterol from the plasma membrane and the endocytic recycling compartment to the endoplasmic reticulum and perhaps other intracellular compartments as well. | 23033213 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
STAR4_HUMAN,
B0AZS2_HUMAN
UniprotKB:
Q96DR4,
B0AZS2
UniParc:
UPI0000136135,
UPI000020C3ED,
UPI000000DA0C
EMBL:
CH471086,
AK054566,
AK315869,
AC011422,
AF480299,
AK315863,
BC042956
Ensembl:
ENSG00000164211
KO:
hsa:134429
|
| Nucleutide sequences |
EMBL-CDS:
BAB70759.1,
AAH42956.1,
AAL87129.1,
EAW49029.1,
BAF98760.1,
BAF98754.1,
EAW49028.1
Gene_ORFName:
hCG_37443
Ensembl_TRS:
ENST00000296632,
ENST00000505803,
ENST00000502322
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000296632,
ENSP00000427639,
ENSP00000427478
RefSeq:
NP_001294988.1,
NP_001294990.1,
NP_001294987.1,
XP_024310132.1,
XP_016864533.1,
XP_016864532.1,
NP_001294989.1,
NP_631903.1,
NP_001294986.1,
XP_016864530.1,
NP_001294985.1,
XP_016864531.1
|
| Others |
UniRef100:
UniRef100_Q96DR4,
UniRef100_B0AZS2
UniRef90:
UniRef90_Q96DR4,
UniRef90_A0A2R9BUG8
UniRef50:
UniRef50_Q96DR4
UniGene:
Hs.93842
CCDS:
CCDS4104.1,
CCDS78046.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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