| Type | Description |
|---|---|
| Definition | deoxyribonuclease 1-like 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:29:00 | Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction. | 33022220 |
| 2020-07-11 12:11:00 | Cell-free DNA in blood circulation is generated by DNase1L3 and caspase-activated DNase. | 31255286 |
| 2019-03-16 10:12:00 | These results support a distinct role of DNASE1L3 as a regulator of the physical form and availability of cell-free DNA and may have important implications for the mechanism whereby this enzyme prevents autoimmunity. | 30593563 |
| 2018-03-17 10:47:00 | DNase1 and DNase1-like 3 are independently expressed and thus provide dual host protection against deleterious effects of intravascular neutrophil extracellular traps. | 29191910 |
| 2017-01-14 11:39:00 | Study reports that DNASE1L3-deficient mice rapidly develop autoantibodies to DNA and chromatin, followed by an systemic lupus erythematosus-like disease. Circulating DNASE1L3 is produced by dendritic cells and macrophages, and its levels inversely correlate with anti-DNA antibody response. | 27293190 |
| Type | IDs |
|---|---|
| Synonymous | DNasegamma, Dhp2, Lsd |
| Gene |
UniProtKB-ID:
DNSL3_MOUSE
UniprotKB:
O55070
UniParc:
UPI0000000604
EMBL:
AF047355,
BC012671,
U76110,
AY024355
Ensembl:
ENSMUSG00000025279
KO:
mmu:13421
|
| Nucleutide sequences |
EMBL-CDS:
AAK07733.1,
AAC35753.1,
AAD09222.1,
AAH12671.1
Ensembl_TRS:
ENSMUST00000026315
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000026315
RefSeq:
NP_031896.3,
XP_006517984.1
|
| Others |
UniRef100:
UniRef100_O55070
UniRef90:
UniRef90_O55070
UniRef50:
UniRef50_Q13609
UniGene:
Mm.272258,
Mm.490513
CCDS:
CCDS26807.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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