| Type | Description |
|---|---|
| Definition | deoxyribonuclease I |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 12:08:00 | this model recapitulates the female bias seen in human SLE patients since female Dnase1-deficient mice produced the highest concentrations of autoantibodies and had more severe kidney damage than males. | 30758851 |
| 2018-03-17 10:47:00 | DNase1 and DNase1-like 3 are independently expressed and thus provide dual host protection against deleterious effects of intravascular neutrophil extracellular traps. | 29191910 |
| 2013-10-26 13:56:00 | HMGN1 binds to CpG island-containing promoters and affects the organization of nucleosomes, DNase I hypersensitivity, and the transcriptional profile of mouse embryonic stem cells and neural progenitors. | 23775126 |
| 2013-08-10 12:21:00 | Early mesangial nephritis initiates a cascade of inflammatory signals that lead to up-regulation of Trap1 and a consequent down-regulation of renal DNaseI by transcriptional interference. | 23273922 |
| 2012-11-17 10:24:00 | silencing of renal DNaseI gene expression initiates a cascade of inflammatory signals including activation of Toll like receptors and Clec4e, leading to progression of both murine and human lupus nephritis | 22479529 |
| Type | IDs |
|---|---|
| Synonymous | AI788650, DNaseI, Dnl1 |
| Gene |
UniProtKB-ID:
DNAS1_MOUSE,
Q14BW6_MOUSE
UniprotKB:
P49183,
Q14BW6
UniParc:
UPI0000020F1B
EMBL:
BC115571,
U00478,
D83038
Ensembl:
ENSMUSG00000005980
KO:
mmu:13419
|
| Nucleutide sequences |
EMBL-CDS:
BAA28622.1,
AAA03710.1,
AAI15572.1
Ensembl_TRS:
ENSMUST00000120009,
ENSMUST00000006136
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000113119,
ENSMUSP00000006136
RefSeq:
NP_001344072.1,
NP_034191.3,
XP_006521839.1,
XP_006521838.1
|
| Others |
UniRef100:
UniRef100_P49183
UniRef90:
UniRef90_P49183
UniRef50:
UniRef50_P49183
UniGene:
Mm.440565
CCDS:
CCDS27913.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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