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132864 CPEB2

132864

CPEB2

cytoplasmic polyadenylation element binding protein 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition cytoplasmic polyadenylation element binding protein 2

研究结论

Date Results Publications
2020-06-20 11:18:00 Data demonstrated an increased occurrence of both SRSF3 and the CPEB2B isoform in triple negative breast cancer (TNBC), and identified a consensus binding motif for SRSF3 in the exon promoting the CPEB2B isoform. The study also suggests that the splicing event, which promotes the expression of CPEB2B, is driven by SRSF3 as well as linked to aggressive growth in metastatic TNBC. 31138601
2019-12-14 12:35:00 CPEB2, presumably the isoform A, plays a key role in suppressing tumorigenesis in mammary epithelial cells by repressing EMT, migration, invasion, proliferation and stem-like cells phenotype, via multiple targets, including a newly-identified translational target p53. 31185986
2018-03-10 10:36:00 Our findings demonstrated the overexpression of miR-885-5p in liver metastasis and its roles in inducing CRC metastasis, potentiating development of miR-885-5p inhibitor to treat advanced CRC in the future. 28460469
2017-09-02 13:01:00 Long non-coding RNA TUG1 mediates methotrexate resistance in colorectal cancer via miR-186/CPEB2 axis. 28302487
2017-05-06 20:40:00 long non-coding RNA CCAT1 regulates the sensitivity of paclitaxel in nasopharyngeal carcinoma cells via miR-181a/CPEB2 axis. 28358263

名称对应

Type IDs
Synonymous CPE-BP2, CPEB-2, hCPEB-2
Gene
UniProtKB-ID: CPEB2_HUMAN, A0A5K1VW71_HUMAN, A0A5K1VW61_HUMAN, A0A5K1VW79_HUMAN, A0A5K1VW93_HUMAN
UniprotKB: Q7Z5Q1, A0A5K1VW71, A0A5K1VW61, A0A5K1VW79, A0A5K1VW93
UniParc: UPI0001D0434D, UPI00001AE452, UPI00005B7289, UPI0000E8A8B1, UPI0001D04352, UPI00005CE281, UPI0000EADF1F, UPI0001D0434B, UPI0001D04351, UPI0001D0434C, UPI0001D0434A, UPI00001AE453
EMBL: AC114749, BC103939, BC103941, BC103942, AC105289, AY247744, BC105925, AY255519, AC098829, BC103940
Ensembl: ENSG00000137449
KO: hsa:132864
Nucleutide sequences
EMBL-CDS: AAI03942.1, AAI05926.1, AAP41553.1, AAI03943.1, AAI03940.2, AAI03941.1, AAP37585.1
Ensembl_TRS: ENST00000442003, ENST00000538197, ENST00000382395, ENST00000345451, ENST00000382401, ENST00000507071
Protein sequencees
Ensembl_PRO: ENSP00000414270, ENSP00000443985, ENSP00000371832, ENSP00000334058, ENSP00000371838, ENSP00000424084
RefSeq: XP_016863223.1, NP_001170854.1, XP_011512079.1, XP_011512080.1, XP_011512081.1, NP_001170852.1, NP_001170853.1, XP_016863222.1, XP_005248192.2, NP_001170855.1, NP_872291.2, NP_872587.2
Others
UniRef100: UniRef100_A0A5K1VW71, UniRef100_Q7Z5Q1, UniRef100_A0A5K1VW79, UniRef100_A0A5K1VW61
UniRef90: UniRef90_A0A5K1VW61, UniRef90_A0A5K1VW71, UniRef90_Q7Z5Q1, UniRef90_A0A5K1VW79
UniRef50: UniRef50_Q812E0
UniGene: Hs.656937
CCDS: CCDS56326.1, CCDS56325.1

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