| Type | Description |
|---|---|
| Definition | defensin, alpha 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-11-30 11:52:00 | The authors show that the antimicrobial peptide alpha-defensin is functionally sustained during nutrient deprivation because of regulation of the defensin-processing enzyme MMP7 by microbiota- and host-derived factors. Sustained Mmp7 expression requires the microbiota and is mediated by de-repression of the transcription activator Atoh1 upon attenuation of the transcriptional repressor Hes1 in intestinal epithelial cells. | 31053533 |
| 2019-05-04 11:48:00 | we engineered a monoclonal antibody against HNP-1 to block the interaction with P2X7 and found that the blocking antibody protected mice carrying high copy number of DEFA1/DEFA3 from lethal sepsis. We thus demonstrate that DEFA1/DEFA3 copy number variation strongly modulates sepsis development in vivo and explore a paradigm for the precision treatment of sepsis tailored by individual genetic information. | 30718392 |
| 2017-12-23 12:17:00 | Mouse adenovirus 2 infection was enhanced by enteric alpha-defensins. | 28622386 |
| 2011-01-01 10:43:00 | Decreased alpha-defensin is associated with intestinal inflammation in a model of inflammatory bowel disease. | 20222124 |
| 2010-01-21 00:00:00 | cryptdin-1 and cryptdin-4 exhibit circadian oscillation | 16129697 |
| Type | IDs |
|---|---|
| Synonymous | Defcr, Defcr1 |
| Gene |
UniProtKB-ID:
DEFA1_MOUSE
UniprotKB:
P11477
UniParc:
UPI000002797D
EMBL:
U02995,
X15617,
M33225,
U02994
KO:
mmu:13216
|
| Nucleutide sequences |
EMBL-CDS:
CAA33636.1,
AAB60675.1,
AAA63296.1
|
| Protein sequencees |
RefSeq:
NP_034161.2
|
| Others |
UniRef100:
UniRef100_P11477
UniRef90:
UniRef90_P50704
UniRef50:
UniRef50_P50704
UniGene:
Mm.425522
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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