| Type | Description |
|---|---|
| Definition | growth arrest and DNA-damage-inducible 45 alpha |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:44:00 | GADD45alpha drives brown adipose tissue formation through upregulating PPARgamma in mice. | 32719383 |
| 2019-12-28 10:38:00 | Gene analyses identify high Pdyn and Il6 levels in the amygdala as indicative of enhanced nociceptive hypersensitivity and reveal an association between high Gadd45 expression and attenuated emotional and cognitive manifestations of neuropathic pain. | 30668942 |
| 2019-10-05 10:11:00 | Gadd45a silencing increases tumor cell proliferation and reduces apoptosis and senescence through the p53 signaling pathway in skin squamous cell carcinoma. | 29663367 |
| 2019-09-14 11:00:00 | Gadd45a,b double-mutant mouse embryos display embryonic sublethality, deregulated ZGA gene expression, and developmental arrestrevealing an unexpected role of GADD45 proteins in embryonic two-cell stage regulation | 31171699 |
| 2019-06-08 10:36:00 | Mechanistically, Gadd45a facilitates the generation of a permissive chromatin state for DNA damage response (DDR) signaling by inducing base excision repair-dependent demethylation of CpG islands specifically at sub-telomeric regions of short telomeres. Deletion of Gadd45a promotes chromatin compaction in sub-telomeric regions and attenuates DDR initiation at short telomeres of G3Terc (-/-) ISCs | 30126922 |
| Type | IDs |
|---|---|
| Synonymous | AA545191, Ddit1, GADD45 |
| Gene |
UniProtKB-ID:
GA45A_MOUSE,
Q3UMH6_MOUSE
UniprotKB:
P48316,
Q3UMH6
UniParc:
UPI0000001902
EMBL:
U00937,
BC011141,
L28177,
AK144900
Ensembl:
ENSMUSG00000036390
KO:
mmu:13197
|
| Nucleutide sequences |
EMBL-CDS:
AAH11141.1,
AAC27351.1,
AAA37656.1,
BAE26122.1
Ensembl_TRS:
ENSMUST00000043098
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000044034
RefSeq:
NP_031862.1
|
| Others |
UniRef100:
UniRef100_P48316
UniRef90:
UniRef90_P48316
UniRef50:
UniRef50_P48316
UniGene:
Mm.72235
CCDS:
CCDS20217.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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