| Type | Description |
|---|---|
| Definition | G protein-coupled receptor kinase 7 |
| Date | Results | Publications |
|---|---|---|
| 2012-04-14 10:49:00 | Defects in GRK1 or GRK7 cause patients to suffer from an inability to properly deactivate rhodopsin leading to problems with recovery and dark adaptation. | 22183412 |
| 2010-09-15 22:06:00 | Observational study of gene-disease association. (HuGE Navigator) | 19913121 |
| 2010-09-15 22:06:00 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | 20628086 |
| 2010-06-30 22:06:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| 2010-01-21 00:00:00 | Phosphorylation of GRK1 and GRK7 by occurs in the dark, when cAMP levels in photoreceptor cells are elevated. | 15946941 |
| Type | IDs |
|---|---|
| Synonymous | GPRK7 |
| Gene |
UniProtKB-ID:
GRK7_HUMAN
UniprotKB:
Q8WTQ7
UniParc:
UPI000004244D
EMBL:
AF282269,
AF439409,
AC112504
Ensembl:
ENSG00000114124
KO:
hsa:131890
|
| Nucleutide sequences |
EMBL-CDS:
AAL48216.1,
AAL33880.1
Ensembl_TRS:
ENST00000264952
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000264952
RefSeq:
NP_631948.1
|
| Others |
UniRef100:
UniRef100_Q8WTQ7
UniRef90:
UniRef90_Q8WTQ7
UniRef50:
UniRef50_Q8WTQ7
UniGene:
Hs.680654
CCDS:
CCDS3120.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 22939624 |
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell Mikko Taipale , Irina Krykbaeva , Martina Koeva , Can Kayatekin , Kenneth D Westover , Georgios I Karras , Susan Lindquist |
2012-08-31 |
NR1H3,
TRIM10,
SGK2,
PREB,
CDK3,
TNK2,
CDK4,
CDK6,
CDK7,
CDK9,
LOC400927-CSNK1E,
PCGF3,
TESK2,
MERTK,
KAT5,
CEBPE,
NPRL2,
CAMKK2,
MAP3K2,
FASTK,
RCBTB2,
PIM2,
WWP1,
CHEK1,
CDC37,
MAP4K1,
IRAK3,
TP53RK,
STK38,
KLHL32,
KLHL29,
FBXO17,
CLK2,
CLK3,
FBXO27,
ASB17,
RNF19B,
ACVR1C,
GRK7,
MAP3K8,
ASB6,
MYO3B,
RAB40A,
CSF1R,
FBXL14,
CSNK1A1,
CSNK1E,
HIPK4,
PDIK1L,
KLHL23,
SH3RF2,
SGK223,
DAPK3,
DCLK2,
ZBTB49,
DLX6,
DMPK,
EGFR,
EPHA2,
EPHA1,
EPHA4,
EPHB1,
EPHB6,
ERBB2,
ERBB3,
ERBB4,
AKT2,
ESR1,
PTK2B,
FBXL13,
FER,
FES,
MAPK15,
FGFR1,
FGFR3,
FGR,
ICK,
TRIM32,
TCF25,
STK38L,
FOXM1,
MAST2,
PASK,
LARP4B,
FBXO28,
DTX4,
FLT4,
ZC3H7B,
FBXW11,
TRIM2,
SF3B3,
TSSK2,
SGK3,
ALK,
FRK,
ABL1,
FYN,
KLHL34,
FBXL2
|
| 22183412 |
A tale of two kinases in rods and cones. Adv. Exp. Med. Biol. Shoji Osawa , Ellen R Weiss |
2012-01-01 |
GRK7,
GRK1
|
| 20628086 |
Diabetes Care Swneke D Bailey , Changchun Xie , Ron Do , Alexandre Montpetit , Rafael Diaz , Viswanathan Mohan , Bernard Keavney , Salim Yusuf , Hertzel C Gerstein , James C Engert , Sonia Anand , DREAM investigators |
2010-10-01 | - |
| 20379614 |
Mol. Med. Jed E Rose , Frédérique M Behm , Tomas Drgon , Catherine Johnson , George R Uhl |
2010-03-17 | - |
| 19913121 |
Am. J. Hum. Genet. Philippa J Talmud , Fotios Drenos , Sonia Shah , Tina Shah , Jutta Palmen , Claudio Verzilli , Tom R Gaunt , Jacky Pallas , Ruth Lovering , Kawah Li , Juan Pablo Casas , Reecha Sofat , Meena Kumari , Santiago Rodriguez , Toby Johnson , Stephen J Newhouse , Anna Dominiczak , Nilesh J Samani , Mark Caulfield , Peter Sever , Alice Stanton , Denis C Shields , Sandosh Padmanabhan , Olle Melander , Claire Hastie , Christian Delles , Shah Ebrahim , Michael G Marmot , George Davey Smith , Debbie A Lawlor , Patricia B Munroe , Ian N Day , Mika Kivimaki , John Whittaker , Steve E Humphries , Aroon D Hingorani , ASCOT investigators , NORDIL investigators , BRIGHT Consortium |
2009-11-01 | - |
| 19953087 |
Mol. Syst. Biol. Avinash Persaud , Philipp Alberts , Eva M Amsen , Xuejian Xiong , James Wasmuth , Zachary Saadon , Chris Fladd , John Parkinson , Daniela Rotin |
2009-01-01 |
Nedd4,
Nedd4l,
Acvr1b,
Cacnb1,
AKT3,
TOM1,
SGK2,
CDK3,
CDK5,
UBAC1,
BAIAP2,
MERTK,
STK25,
SIVA1,
RBCK1,
RAD51AP1,
CAMKK2,
MAP3K2,
PLK2,
SEPT9,
MAP4K5,
PRRT2,
SAAL1,
CLIC2,
CLK3,
MOB3A,
GRK7,
MAP3K8,
SPANXN3,
TCP10L,
TCEAL2,
CSNK2A1,
BEAN1,
TOM1L2,
DIRAS1,
GRK2,
DAPK3,
TCEANC,
ACAN,
EGFR,
EIF5,
MARK2,
DMTN,
EPHA5,
AKT1,
RASGEF1A,
FES,
FGF12,
FGFR1,
FGFR2,
FKBP3,
UBOX5,
RTF1,
FLT1,
SULF1,
FLT4,
NEDD4L,
WBP2,
ABL1,
FYN,
DECR2,
SPAG8,
FGF21,
GBA,
TIMM10,
RNF11,
AMPD2,
ABL2,
APEX2,
ZADH2,
GRK4,
TBK1,
EFEMP2,
H1F0,
SERPIND1,
ANKRD13D,
AQP9,
IRS1,
KCNB1,
KIFC3,
CUEDC1,
SMAD3,
MAGEB1,
MAP2,
MAP3K3,
MAP3K5,
NEDD4,
NTRK1,
NTRK2,
MINK1,
TBC1D7,
ZDHHC3,
PRR16,
PDGFRA,
PDGFRB,
LUC7L2,
SERPINF1,
STK26,
ZAK
|
| 18266817 |
Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin. Photochem. Photobiol. Aya Torisawa , Daisuke Arinobu , Shuji Tachibanaki , Satoru Kawamura |
2008-02-07 |
GRK7,
RCVRN,
GRK1
|
| 17286855 |
Mapping of transcription start sites of human retina expressed genes. BMC Genomics Valeria Roni , Ronald Carpio , Bernd Wissinger |
2007-01-01 |
NXNL1,
WDR17,
CNGA3,
GRK7,
CRX,
RDH12,
EYA3,
AIPL1,
ABCA4,
SLC24A2,
FSCN2,
LRIT1,
PRPF31,
CLUL1,
GNAT1,
CRB2,
GUCY2D,
AOC2,
HPCA,
IMPG1,
KIFC3,
ILDR2,
RDH8,
IMPG2,
RDH11,
PDE6H,
CNGB3,
MPP4,
RBP3,
RCVRN,
RDH5,
PRPH2,
RGR,
RLBP1,
ELOVL5,
ROM1,
RP1,
RPGR,
RS1,
SAG,
ELOVL4,
TULP1,
DHRS3,
OPN4,
C14orf2
|
| 15946941 |
J Biol Chem Thierry J Horner , Shoji Osawa , Michael D Schaller , Ellen R Weiss |
2005-08-05 | - |
| 16473576 |
Meth. Enzymol. Houbin Zhang , Suzanne Hosier , Jennifer M Terew , Kai Zhang , Rick H Cote , Wolfgang Baehr |
2005-01-01 |
GRK7,
RAB8A,
PDE6D,
GRK1
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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