| Type | Description |
|---|---|
| Definition | disabled 2, mitogen-responsive phosphoprotein |
| Date | Results | Publications |
|---|---|---|
| 2019-07-13 12:28:00 | Dab2 deficiency in myeloid cells promotes inflammation in livers and atherosclerotic plaques in an Ldl receptor knockout mouse model of atherosclerosis. | 29599136 |
| 2019-07-06 11:21:00 | we found that knockdown of Dab2 reduced the uptake of VEGF in LSECs, furthermore blocking VEGF-mediated LSEC dedifferentiation and angiogenesis | 29044176 |
| 2019-06-29 10:28:00 | Suppression of Dab2 resulted in increased proliferation, loss of contact inhibition, morphological dysplasia, and resistance to oncogene-induced senescence - all factors that can sensitize ovarian surface epithelium to transformation. | 29196616 |
| 2019-05-11 11:50:00 | Putative causal genes were enriched for proximal tubule expression and endolysosomal function, where DAB2, an adaptor protein in the TGF-b pathway, formed a central node. Functional experiments confirmed that reducing Dab2 expression in renal tubules protected mice from Chronic kidney disease. | 30275566 |
| 2018-09-29 12:15:00 | miR149 was able to target Dab2 and promote the cardiac differentiation of mouse MSCs in vitro, which depended upon the Wnt/betacatenin signaling pathway. | 29693140 |
| Type | IDs |
|---|---|
| Synonymous | 5730435J12Rik, AA960054, AI957090, D15Wsu122e, D630005B22Rik, Doc-2, Doc2, p96 |
| Gene |
UniProtKB-ID:
DAB2_MOUSE,
E9PX84_MOUSE,
Q3TN55_MOUSE,
E9QL31_MOUSE,
A0A0R4J104_MOUSE,
Q3TRE6_MOUSE,
Q3TRI2_MOUSE
UniprotKB:
P98078,
E9PX84,
Q3TN55,
E9QL31,
A0A0R4J104,
Q3TRE6,
Q3TRI2
UniParc:
UPI00006688AF,
UPI00006688B0,
UPI0000668813,
UPI0000354E04,
UPI0000354E03,
UPI00005B1EC4,
UPI000016CA20,
UPI00005B2163,
UPI0000F4B367
EMBL:
AC099884,
BC016887,
U18869,
AF260580,
AK165519,
BC006588,
AK162851,
AK162744,
AC105324,
AK154716
Ensembl:
ENSMUSG00000022150
KO:
mmu:13132
|
| Nucleutide sequences |
EMBL-CDS:
AAH16887.1,
AAG44669.1,
AAH06588.1,
BAE32784.1,
AAB02647.1,
AAB02645.1,
AAB02646.1,
BAE38234.1,
BAE37084.1,
BAE37047.1
Ensembl_TRS:
ENSMUST00000161812,
ENSMUST00000110664,
ENSMUST00000080880,
ENSMUST00000078019,
ENSMUST00000110663
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000124589,
ENSMUSP00000106292,
ENSMUSP00000079689,
ENSMUSP00000106291,
ENSMUSP00000077166
RefSeq:
NP_001008702.1,
NP_001032994.1,
NP_075607.2,
XP_030104172.1,
XP_017171913.1,
XP_011243626.1,
XP_030104173.1,
NP_001297375.1,
NP_001095870.1
|
| Others |
UniRef100:
UniRef100_E9QL31,
UniRef100_Q3TRI2,
UniRef100_P98078,
UniRef100_Q3TN55,
UniRef100_Q3TRE6,
UniRef100_A0A0R4J104,
UniRef100_E9PX84
UniRef90:
UniRef90_P98078,
UniRef90_P98078-3
UniRef50:
UniRef50_P98078-3,
UniRef50_P98078
UniGene:
Mm.240830
CCDS:
CCDS37030.1,
CCDS37029.1,
CCDS79357.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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