| Type | Description |
|---|---|
| Definition | cytochrome P450, family 46, subfamily a, polypeptide 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-26 10:32:00 | Collectively, the data obtained establish metabolic and regulatory significance of CYP46A1 for the retina and suggest pharmacologic activation of CYP46A1 as a potential therapeutic approach to dyslipidemia-induced retinal damage. | 30448403 |
| 2019-08-17 11:43:00 | Enhanced cholesterol turnover by activation of CYP46A1 represents disrupted brain cholesterol homeostasis early after neonatal hypoxia-ischemia | 29718007 |
| 2018-04-21 10:05:00 | Oral administration of a small dose of the anti-HIV drug efavirenz to a mouse model of Alzheimer's disease ameliorated amyloid pathology in the brain and led to changes supporting therapeutic potential of cholesterol-metabolizing enzyme CYP46A1, its metabolite 24HC and 24HC-mediated liver X receptors transrepression of some of the inflammatory genes in astrocytes and microglia surrounding amyloid plaques. | 28655608 |
| 2017-11-25 12:38:00 | The present study demonstrates the diverse potential effects of CYP46A1 deficiency on brain functions and identifies important proteins that could be affected by this deficiency | 29073233 |
| 2016-07-30 11:44:00 | Increased expression of CYP46A1 in the striatum decreased neuronal atrophy in a Huntington's disease model. | 26912634 |
| Type | IDs |
|---|---|
| Synonymous | CH24H, Cyp46 |
| Gene |
UniProtKB-ID:
CP46A_MOUSE,
Q3US73_MOUSE
UniprotKB:
Q9WVK8,
Q3US73
UniParc:
UPI000002906E
EMBL:
BC018307,
AF094479,
AK140740
Ensembl:
ENSMUSG00000021259
KO:
mmu:13116
|
| Nucleutide sequences |
EMBL-CDS:
AAH18307.1,
AAD41243.1,
BAE24462.1
Ensembl_TRS:
ENSMUST00000021684
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000021684
RefSeq:
NP_034140.1,
XP_030102395.1
|
| Others |
UniRef100:
UniRef100_Q9WVK8
UniRef90:
UniRef90_Q9Y6A2
UniRef50:
UniRef50_Q9Y6A2
UniGene:
Mm.41911
CCDS:
CCDS26160.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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