| Type | Description |
|---|---|
| Definition | cytochrome P450, family 27, subfamily b, polypeptide 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:28:00 | Modified expression of vitamin D receptor and CYP27B1 in denervation-induced muscle atrophy. | 32736700 |
| 2020-08-15 19:05:00 | 25(OH)D3 stimulates the expression of vitamin D target genes in renal tubular cells when Cyp27b1 is abrogated. | 31945466 |
| 2020-07-25 12:03:00 | Study in knockout mice provides evidence that bone 1alpha-hydroxylase Cyp27b1 may play a central role in the regulation of sclerostin, BMP2, and FGF23 in chronic kidney disease. Increased osteocytic 1,25(OH)2D production, triggered by renal malfunction, may represent a "primary defensive response" to protect the organism from ectopic calcification by increasing sclerostin and suppressing BMP2 production. | 31292298 |
| 2020-02-29 12:09:00 | Deletion of both submodules eliminated basal Cyp27b1 expression and regulation in the kidney, leading to systemic and skeletal phenotypes similar to those of Cyp27b1-null mice | 31053643 |
| 2019-12-21 11:44:00 | Glutathione deficiency alters the vitamin D-metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of high-fat diet fed mice. | 30578920 |
| Type | IDs |
|---|---|
| Synonymous | Cp2b, Cyp1, Cyp27b, Cyp40, P450c1, Pddr, Vdd1, Vddr, VddrI, Vdr |
| Gene |
UniProtKB-ID:
CP27B_MOUSE,
Q66JY8_MOUSE
UniprotKB:
O35084,
Q66JY8
UniParc:
UPI0000020FC4,
UPI000042847E
EMBL:
AF286219,
AF235021,
AB006034,
BC080697
Ensembl:
ENSMUSG00000006724
KO:
mmu:13115
|
| Nucleutide sequences |
EMBL-CDS:
AAG44889.1,
BAA22434.1,
AAK15024.1,
AAH80697.1
Ensembl_TRS:
ENSMUST00000165764
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000130005
RefSeq:
XP_006513250.1,
NP_034139.2
|
| Others |
UniRef100:
UniRef100_Q66JY8,
UniRef100_O35084
UniRef90:
UniRef90_O35084
UniRef50:
UniRef50_O15528
UniGene:
Mm.6216
CCDS:
CCDS24224.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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