| Type | Description |
|---|---|
| Definition | cytochrome P450, family 1, subfamily b, polypeptide 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-11-21 13:24:00 | 6beta-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice. | 31948482 |
| 2020-10-31 13:12:00 | Obesity alters oestrogen metabolism and contributes to pulmonary arterial hypertension. | 30923189 |
| 2020-07-18 10:25:00 | Study determined changes in the transcriptome profiles of Cyp1b1+/+ and Cyp1b1-/- retinal astrocytes (AC) by RNA sequencing and identified 585 differentially expressed genes. Results of the first report of RNA-seq investigation of the retinal AC transcriptome and the molecular pathways impacted by Cyp1b1 expression demonstrated an important role for Cyp1b1 expression in the regulation of various retinal AC functions. | 32330152 |
| 2020-05-09 12:19:00 | Ultraviolet A (UVA) induced oxidative stress, DNA damage, and estrogen-DNA adducts in mouse corneal endothelium (CE) recapitulates Fuchs endothelial corneal dystrophy (FECD). Results identified involvement of CYP1B1, the key estrogen-metabolizing enzyme, in sex-dependent differences in CE susceptibility to UVA and detected greater mtDNA damage and estrogen-DNA adduct formation in more severely affected female mice. | 31852820 |
| 2020-05-02 12:21:00 | Cyp1b1-/- suppresses genes supported by Srebp. Gestational vitamin A deficiency (dietary retinal defiiency during pregnancy) effects distinguish Srebp1 and Srebp2 mediation. Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver. | 32027669 |
| Type | IDs |
|---|---|
| Synonymous | CP1B, CYPIB1, P4501b1 |
| Gene |
UniProtKB-ID:
CP1B1_MOUSE
UniprotKB:
Q64429
UniParc:
UPI0000022237
EMBL:
U03283,
AK137461,
CH466537,
U02479,
X78445
Ensembl:
ENSMUSG00000024087
KO:
mmu:13078
|
| Nucleutide sequences |
EMBL-CDS:
BAE23362.1,
AAC52141.1,
AAC52131.1,
EDL38490.1,
CAA55205.1
Ensembl_TRS:
ENSMUST00000024894
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000024894
RefSeq:
NP_034124.1,
NP_001351818.1
|
| Others |
UniRef100:
UniRef100_Q64429
UniRef90:
UniRef90_Q64429
UniRef50:
UniRef50_Q64429
UniGene:
Mm.214016
CCDS:
CCDS28986.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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