| Type | Description |
|---|---|
| Definition | arylacetamide deacetylase |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 13:16:00 | Study investigated the presence and activity of the AADAC enzyme in several human lungs. Results highlight high interindividual variability in both AADAC gene and protein expression as well as in phenacetin hydrolysis activity. These findings add more information to knowledge of pulmonary enzymes and could be particularly useful in the design and preclinical development of inhaled drugs. | 31235486 |
| 2020-03-14 12:37:00 | AADAC rs1803155 single nucleotide polymorphism is associated with lower rifapentine clearance, leading to increased rifapentine exposure. | 30670438 |
| 2018-12-22 10:47:00 | that the AADAC gene c.361+1G>A variant may be a potential candidate factor for Tourette syndrome development | 29253601 |
| 2017-08-19 11:36:00 | Data suggest that metabolism (and possibly pharmacokinetics) of hypnotic nitrazepam involves liver enzymes AOX1 (aldehyde oxidase 1), NAT2 (N-acetyltransferase 2), AADAC (arylacetamide deacetylase), and CYP3A4 (cytochrome P450 3A4). | 28606603 |
| 2017-05-13 13:42:00 | Data suggest that AADAC in hepatocyte microsomes hydrolyzes ketoconazole, a synthetic imidazole antifungal agent, to N-deacetyl ketoconazole and thus triggers hepatocellular toxicity. | 27422753 |
| Type | IDs |
|---|---|
| Synonymous | CES5A1, DAC |
| Gene |
UniProtKB-ID:
AAAD_HUMAN
UniprotKB:
P22760
UniParc:
UPI000006D992
EMBL:
CH471052,
BC032309,
L32179,
AC068647,
AK290628
Ensembl:
ENSG00000114771
KO:
hsa:13
|
| Nucleutide sequences |
EMBL-CDS:
BAF83317.1,
AAA35551.1,
EAW78792.1,
EAW78791.1,
AAH32309.1
Ensembl_TRS:
ENST00000232892
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000232892
RefSeq:
XP_005247161.1,
NP_001077.2
|
| Others |
UniRef100:
UniRef100_P22760
UniRef90:
UniRef90_P22760
UniRef50:
UniRef50_P22760
UniGene:
Hs.506908
CCDS:
CCDS33877.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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