| Type | Description |
|---|---|
| Definition | crystallin, alpha A |
| Date | Results | Publications |
|---|---|---|
| 2020-02-22 12:04:00 | We show that many crystallins are upregulated in a murine model of RD and that alphaA-crystallin shows the highest level of expression both on the transcriptional and translational levels. We further found a significant upregulation of alphaA-crystallin in vitreous samples of human pseudophakic RD patients | 31550446 |
| 2020-02-22 11:52:00 | alpha-Crystallin isolated from SIRT3 and SIRT5 KO lenses displayed a higher surface hydrophobicity and higher chaperone activity than the protein isolated from WT lenses. Thus, SIRTs regulate the acetylation levels of crystallins in mouse lenses, and acetylation in lenses enhances the chaperone activity of alpha-crystallin. | 30849386 |
| 2019-12-07 10:49:00 | Study using mouse streptozotocin diabetes model demonstrated the neuroprotective role of alphaA-crystallin during diabetes and its regulation by its phosphorylation on residue 148 and further characterized the dual role of alphaA-crystallin in neurons and glia, its essential role for neuronal survival, and its direct dependence on phosphorylation on this residue. | 29467334 |
| 2018-02-10 10:34:00 | findings offer additional insight into the early transcriptional changes caused by Cryaa and Cryab mutations associated with autosomal dominant cataracts, and indicate that the transcript levels of certain genes are affected by the expression of mutant alpha-crystallin in vivo | 29338044 |
| 2016-07-16 10:13:00 | Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf. | 26719333 |
| Type | IDs |
|---|---|
| Synonymous | Acry-1, Crya-1, Crya1, DAcry-1, lop18 |
| Gene |
UniProtKB-ID:
CRYAA_MOUSE,
Q569M7_MOUSE,
Q546L9_MOUSE,
A0A494B9Q6_MOUSE
UniprotKB:
P24622,
Q569M7,
Q546L9,
A0A494B9Q6
UniParc:
UPI0000021348,
UPI0000000AEE,
UPI0003513CFB
EMBL:
AJ310308,
AK143463,
BC085170,
BC092385,
J00376,
AC090881,
V00730,
J00375,
BC085172
Ensembl:
ENSMUSG00000024041
KO:
mmu:12954
|
| Nucleutide sequences |
EMBL-CDS:
AAA37470.1,
AAA37471.1,
CAA24108.2,
AAA37469.1,
CAA24109.2,
AAH85172.1,
AAH92385.1,
BAE25387.1,
AAH85170.1,
CAC35974.1
Ensembl_TRS:
ENSMUST00000228716,
ENSMUST00000019192,
ENSMUST00000228089
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000019192,
ENSMUSP00000154747,
ENSMUSP00000157708
RefSeq:
NP_038529.1,
NP_001265498.1,
NP_001265499.1
|
| Others |
UniRef100:
UniRef100_P68405,
UniRef100_P24622,
UniRef100_A0A494B9Q6
UniRef90:
UniRef90_P24622,
UniRef90_P02470
UniRef50:
UniRef50_P02470,
UniRef50_P24622
UniGene:
Mm.1228
CCDS:
CCDS89061.1,
CCDS37551.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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