| Type | Description |
|---|---|
| Definition | carnitine acetyltransferase |
| Date | Results | Publications |
|---|---|---|
| 2019-09-21 10:12:00 | we modeled mitochondrial overload by creating mice lacking the enzyme carnitine acetyltransferase (CrAT) in the proximal tubules, thus limiting a primary mechanism to export carbons under conditions of substrate excess. Mice developed tubular disease and, interestingly, secondary glomerulosclerosis. This was accompanied by increased levels of apoptosis, fibrosis and oxidative stress. | 30728184 |
| 2019-06-08 10:38:00 | AgRP neurons require Crat to provide the metabolic flexibility to optimize nutrient partitioning and regulate peripheral substrate utilization, particularly during fasting and refeeding. | 29444428 |
| 2019-02-09 11:42:00 | Crat within AgRP neurons forms a component of the homeostatic response to restricted feeding but is not likely to be a molecular component of Food-entrainable oscillator. | 29697769 |
| 2019-01-12 10:56:00 | Presence of a cytosolic CrAT with a low Km for CoA, favoring the formation of cytosolic acetyl-CoA, providing an additional source to the classical ATP-citrate lyase pathway; there is an inverse relation between CrAT and the ratio of acetyl-CoA/CoA as evident in conditions affecting the regulation of cardiac energy metabolism. | 29438065 |
| 2018-10-20 10:19:00 | Studies revealed that ablation of CrAT in myeloid lineage cells did not impact glucose homeostasis, insulin-action, adipose tissue leukocytosis, and inflammation when animals were confronted with a variety of metabolic stressors, including high-fat diet, fasting, or LPS-induced acute endotoxemia. | 28180063 |
| Type | IDs |
|---|---|
| Synonymous | AW107812, CARAT |
| Gene |
UniProtKB-ID:
CACP_MOUSE
UniprotKB:
P47934
UniParc:
UPI00000E5E0D
EMBL:
AK132179,
AL954388,
AL954299,
BC006668,
AK170740,
X85983
Ensembl:
ENSMUSG00000026853
KO:
mmu:12908
|
| Nucleutide sequences |
EMBL-CDS:
AAH06668.1,
BAE41993.1,
CAA59971.1,
BAE21016.1
Ensembl_TRS:
ENSMUST00000102855,
ENSMUST00000028207
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000099919,
ENSMUSP00000028207
RefSeq:
XP_030102925.1,
XP_006497710.1,
XP_030102929.1,
XP_030102932.1,
XP_030102930.1,
NP_031786.2,
XP_030102928.1,
XP_006497709.1,
XP_036013843.1,
XP_006497708.1,
XP_036013845.1,
XP_036013849.1,
XP_030102931.1
|
| Others |
UniRef100:
UniRef100_P47934
UniRef90:
UniRef90_P47934
UniRef50:
UniRef50_P43155
UniGene:
Mm.20396
CCDS:
CCDS15882.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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