| Type | Description |
|---|---|
| Definition | prokineticin receptor 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:55:00 | Molecular screening of PROKR2 gene in girls with idiopathic central precocious puberty. | 33413516 |
| 2020-05-16 10:30:00 | 18 of135 idiopathic hypogonadotropic hypogonadism patients in China carried mutations in PROKR2. Most of the variants were private; however, a PROKR2 (c.533G > C; p.W178S) mutation was identified in 10 independent patients, implying a possible founder mutation. 6 novel PROKR2 mutations led to decreased signaling to various extents. L218P and R270H disrupted Galphaq-dependent signaling but had normal Galphas and ERK1/2 ... | 30576231 |
| 2019-07-27 12:21:00 | infiltrating neutrophils and 4T1 cells abundantly expressed prokineticin-2 (Prok2) and its receptor, Prokr1, respectively. Finally, the administration of 5-FU after the resection of the primary tumor failed to augment lung metastasis in the mice receiving Prokr1-deleted 4T1 cells. | 29643149 |
| 2019-01-05 10:11:00 | Findings suggest that in vitro modeling of WT/Mutant interactions increases the resolution for identifying causal variants, uncovers novel dominant negative mutations, and provides new insights into the pathogenic mechanisms underlying heterozygous PROKR2 variants. | 29161432 |
| 2018-08-25 12:05:00 | EG-VEGF and PROKR2 were highly expressed in colorectal primary lesions compared to positive controls. PROKR1 expression was lower and did not change in tumor specimens. | 29226856 |
| Type | IDs |
|---|---|
| Synonymous | GPR73L1, GPR73b, GPRg2, HH3, KAL3, PKR2, dJ680N4.3 |
| Gene |
UniProtKB-ID:
PKR2_HUMAN,
A8K1T0_HUMAN
UniprotKB:
Q8NFJ6,
A8K1T0
UniParc:
UPI00015DA51C,
UPI000003BCC6
EMBL:
AF506288,
AL121755,
BC104961,
BC104959,
AB084081,
AK289995,
EF577398
Ensembl:
ENSG00000101292
KO:
hsa:128674
|
| Nucleutide sequences |
EMBL-CDS:
AAI04962.1,
AAI04960.1,
ABQ52418.1,
AAM48128.1,
BAC24022.1,
BAF82684.1
Ensembl_TRS:
ENST00000217270
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000217270
RefSeq:
NP_658986.1,
XP_016883135.1
|
| Others |
UniRef100:
UniRef100_Q8NFJ6,
UniRef100_A8K1T0
UniRef90:
UniRef90_Q8NFJ6
UniRef50:
UniRef50_Q8NFJ6
UniGene:
Hs.375029
CCDS:
CCDS13089.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员