| Type | Description |
|---|---|
| Definition | clusterin |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:21:00 | Clusterin overexpression protects against western diet-induced obesity and NAFLD. | 33060605 |
| 2020-08-15 19:03:00 | Study identify apolipoprotein J (ApoJ) as a novel hepatokine targeting muscle glucose metabolism and insulin sensitivity through a LRP2-dependent mechanism, coupled with the insulin receptor (IR) signaling cascade. In muscle, LRP2 is necessary for insulin-dependent IR internalization, an initial trigger for insulin signaling, that is crucial in regulating downstream signaling and glucose uptake. | 32332780 |
| 2020-07-25 11:56:00 | Clusterin was upregulated in the livers of thioacetamide (TAA)-induced and bile duct ligation mouse models of liver fibrosis. Its loss and overexpression promoted and attenuated hepatic fibrosis after TAA injection, respectively. Thus, clusterin plays an important role in hepatic fibrosis. | 31739636 |
| 2019-08-31 13:37:00 | Clusterin deficiency induces renal lipid accumulation by dysregulating the expression of lipid metabolism-related factors and TGFB1, thereby leading to chronic kidney disease. Hence, clusterin may serve as a therapeutic target for lipid-induced chronic kidney disease. | 29563234 |
| 2019-07-27 10:09:00 | The fibrotic response in Clusterin deficient (CLU-/-) mice persisted after bleomycin and it was associated with increased DNA damage, reduced DNA repair responses, and elevated cellular senescence. Remarkably, this pattern mirrored that observed in idiopathic pulmonary fibrosis patients lung tissues. | 29133960 |
| Type | IDs |
|---|---|
| Synonymous | AI893575, ApoJ, Cli, D14Ucla3, SP-40, Sgp-2, Sgp2, Sugp-2 |
| Gene |
UniProtKB-ID:
CLUS_MOUSE,
Q549A5_MOUSE
UniprotKB:
Q06890,
Q549A5
UniParc:
UPI000000081C
EMBL:
BC075668,
AF182509,
S70244,
D14077,
AF248057,
L08235,
L05670
Ensembl:
ENSMUSG00000022037
KO:
mmu:12759
|
| Nucleutide sequences |
EMBL-CDS:
AAA37422.1,
BAA03162.1,
AAA37284.1,
AAB30623.1,
AAH75668.1,
AAF06365.1,
AAF67184.1
Ensembl_TRS:
ENSMUST00000022616
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000022616
RefSeq:
XP_006518566.1,
NP_038520.2,
XP_006518567.1
|
| Others |
UniRef100:
UniRef100_Q06890
UniRef90:
UniRef90_P05371
UniRef50:
UniRef50_P10909
UniGene:
Mm.200608
CCDS:
CCDS36957.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员