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127343 DMBX1

127343

DMBX1

diencephalon/mesencephalon homeobox 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition diencephalon/mesencephalon homeobox 1

研究结论

Date Results Publications
2020-03-28 11:53:00 Authors found that the function of DMBX1 was dependent on p21 (CDKN1A), a key regulator of G1/S cell cycle progression. Co-IP assay revealed that DMBX1 directly bound to another homeobox transcription factor, OTX2. ChIP and luciferase reporter assay confirmed that OTX2 directly interacted with the promoter region of p21 to enhance its transcription, and DMBX1 repressed OTX2-mediated transcription of p21. 30928384
2017-04-08 11:00:00 Results found that CpG sites of C1orf106, DMBX1, and SIK3 mediate the genetic risk of psoriasis in Chinese Han population. 27980695
2010-01-21 00:00:00 no indications were found for an association between the MBX gene and microphthalmia with congenital cataract in humans 17990594

名称对应

Type IDs
Synonymous MBX, OTX3, PAXB
Gene
UniProtKB-ID: DMBX1_HUMAN
UniprotKB: Q8NFW5
UniParc: UPI0000073295, UPI0000070B63
EMBL: CH471059, AB037699, AL137797, AF398527, AF398528
Ensembl: ENSG00000197587
KO: hsa:127343
Nucleutide sequences
EMBL-CDS: AAM90590.1, BAC00920.1, EAX06907.1, AAM90589.1
Ensembl_TRS: ENST00000371956, ENST00000360032
Protein sequencees
Ensembl_PRO: ENSP00000353132, ENSP00000361024
RefSeq: NP_001374704.1, NP_001374705.1, XP_011538970.1, NP_757379.1, NP_671725.1
Others
UniRef100: UniRef100_Q8NFW5
UniRef90: UniRef90_Q8NFW5
UniRef50: UniRef50_Q91ZK4
UniGene: Hs.375623
CCDS: CCDS536.1

全选

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研究热度

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