| Type | Description |
|---|---|
| Definition | chloride channel, voltage-sensitive 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:32:00 | CUL4-DDB1-CRBN E3 Ubiquitin Ligase Regulates Proteostasis of ClC-2 Chloride Channels: Implication for Aldosteronism and Leukodystrophy. | 32466489 |
| 2020-03-07 11:08:00 | a role of ClC-2 in normal aldosterone production beyond the observed pathophysiology, is reported. | 31727896 |
| 2020-01-18 10:10:00 | knock-in mice expressing a constitutively open ClC-2 Cl- channel increases the chloride conductance of zona glomerulosa cells, provoking a strong depolarization. Clcn2op mice display typical features of human primary aldosteronism, including high serum aldosterone in the presence of low renin activity, marked hypertension and hypokalemia. | 31615979 |
| 2019-08-17 12:54:00 | ClC-2 knockout results in less differentiated colonic crypts and increased tumorigenicity associated with colitis via dysregulation of AJ proteins. | 30285466 |
| 2018-06-23 12:02:00 | High fat diet -treated mice lacking ClC-2 showed inhibited hepatic lipid accumulation via regulating lipid metabolism through decreasing sterol regulatory element binding protein (SREBP)-1c expression and its downstream targeting enzymes such as fatty acid synthase (FAS), HMG-CoA reductase (HMGCR) and carboxylase (ACCalpha). | 29550812 |
| Type | IDs |
|---|---|
| Synonymous | AL118368, ClC-2, Clc2, nmf240 |
| Gene |
UniProtKB-ID:
CLCN2_MOUSE
UniprotKB:
Q9R0A1
UniParc:
UPI000016C8C7
EMBL:
BC137625,
AF139724,
AF097415,
AC087898,
CT010490,
BC120699
Ensembl:
ENSMUSG00000022843
KO:
mmu:12724
|
| Nucleutide sequences |
EMBL-CDS:
AAD26466.1,
AAD50604.1,
AAI37626.1,
AAI20700.1
Ensembl_TRS:
ENSMUST00000007207
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000007207
RefSeq:
NP_034030.2,
XP_017172351.1,
XP_006521812.1,
XP_030104812.1
|
| Others |
UniRef100:
UniRef100_Q9R0A1
UniRef90:
UniRef90_P51788-3
UniRef50:
UniRef50_P51788
UniGene:
Mm.177761
CCDS:
CCDS28057.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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