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12686 Elovl3

12686

Elovl3

elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3

protein-coding

Mus musculus

基因描述

Type Description
Definition elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3

研究结论

Date Results Publications
2021-04-17 13:12:00 Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals. 33069870
2020-06-06 10:24:00 Elovl3 knockout, ELOVL3-ablated (E3hom) mice and their wild type littermates were compared. E3hom mice had abnormal ocular phenotypes such as delayed eye opening, weeping eyes, crusty eyelids, eyelid edema, highly vascularized cornea and tarsal plates (TPs), slit eye, and increased tearing. E3hom TPs had abnormal esters, wax esters, and cholesteryl esters of (O)-acylated w-hydroxy fatty acids. 31208226
2020-01-11 12:10:00 lack of either the circadian clock or androgen signaling impairs hepatic Elovl3 expression, highlighting the observation that coordination between the circadian clock and androgen signaling is required to sustain the rhythmic expression of Elovl3 in mouse liver 30862677
2016-05-21 10:09:00 Data (including data from studies in knockout mice) suggest signal transduction via calcitriol/calcitriol receptor regulates expression of Elovl3 (fatty acid elongase 3) and alters fatty acid composition in subcutaneous (not visceral) adipose tissue. 26488808
2011-01-01 10:29:00 that ablation of ELOVL3 leads to reduced adiponectin levels, constrained expansion of adipose tissue, and resistance against diet-induced obesity, a situation that is more exaggerated in female mice 20605947

名称对应

Type IDs
Synonymous CIN-2, Cig30
Gene
UniProtKB-ID: ELOV3_MOUSE, A0A498WFQ4_MOUSE
UniprotKB: O35949, A0A498WFQ4
UniParc: UPI0000029DF9, UPI0003D74DF4
EMBL: BC016468, U97107, AC140233, AF054504
Ensembl: ENSMUSG00000038754
KO: mmu:12686
Nucleutide sequences
EMBL-CDS: AAC06127.1, AAD51088.1, AAH16468.1
Ensembl_TRS: ENSMUST00000237098, ENSMUST00000043739
Protein sequencees
Ensembl_PRO: ENSMUSP00000157465, ENSMUSP00000036357
RefSeq: NP_001361594.1, NP_031729.1
Others
UniRef100: UniRef100_A0A498WFQ4, UniRef100_O35949
UniRef90: UniRef90_O35949
UniRef50: UniRef50_Q9HB03
UniGene: Mm.21806
CCDS: CCDS29871.1

全选

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