| Type | Description |
|---|---|
| Definition | cholinergic receptor, muscarinic 3, cardiac |
| Date | Results | Publications |
|---|---|---|
| 2020-02-22 12:53:00 | A Chrm3 missense T1667C mutation in the last intracellular domain functionally correlated with a rise in BP increased the M3R signalling and resensitization, and adrenal epinephrogenesis. Gene targeting that abolished the M3R function without affecting any of noncoding Chrm3 variants caused a decrease in BP, indicating that the M3R-mediated signalling promotes hypertension. | 30955929 |
| 2020-02-01 10:31:00 | Chrm1 and Chrm3 double knockout chronically diminishes REM sleep to an almost undetectable level. These results suggest that muscarinic acetylcholine receptors, Chrm1 and Chrm3, are essential for REM sleep. | 30157420 |
| 2019-10-26 12:15:00 | Genetic M3R ablation in mouse cells results in improved remyelination and is mediated by acceleration of oligodendrocyte commitment from oligodendrocyte progenitor cells. | 29959237 |
| 2018-10-13 11:28:00 | The expression of M3-mAChR was down-regulated in the myocardium from aged mice and D-galactose-treated mice, while the expression levels of caspase-1 and its downstream molecule IL-1beta were significantly increased. | 30196290 |
| 2017-11-25 15:23:00 | Stimulation of the ERK pathway in Gnb5(-/-) cells by epidermal growth factor restored M3R-stimulated insulin release to near normal levels. Identification of the novel role of Gbeta5-R7 in insulin secretion may lead to a new therapeutic approach for improving pancreatic beta-cell function | 28687610 |
| Type | IDs |
|---|---|
| Synonymous | Chrm-3, M3, M3R |
| Gene |
UniProtKB-ID:
ACM3_MOUSE,
Q542R4_MOUSE
UniprotKB:
Q9ERZ3,
Q542R4
UniParc:
UPI000000414A
EMBL:
S74908,
AF264050,
BC129892,
BC129893,
AK080950
Ensembl:
ENSMUSG00000046159
KO:
mmu:12671
|
| Nucleutide sequences |
EMBL-CDS:
AAB33576.2,
AAG14344.1,
AAI29893.1,
BAC38088.1,
AAI29894.1
Ensembl_TRS:
ENSMUST00000063093,
ENSMUST00000187510
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000140131,
ENSMUSP00000055579
RefSeq:
XP_006516531.1,
NP_150372.1
|
| Others |
UniRef100:
UniRef100_Q9ERZ3
UniRef90:
UniRef90_P08483
UniRef50:
UniRef50_P08483
UniGene:
Mm.342315
CCDS:
CCDS26238.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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