| Type | Description |
|---|---|
| Definition | ankyrin repeat and LEM domain containing 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:18:00 | ANKLE1 N(6) -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability. | 31509622 |
| 2021-03-06 13:28:00 | Human ANKLE1 Is a Nuclease Specific for Branched DNA. | 32866453 |
| 2017-10-14 11:38:00 | We used The Cancer Genome Atlas breast cancer patient data to identify ANKLE1 and ZNF404 as the target genes of candidate TF binding site SNPs in the 19p13.11 and 19q13.31 GWAS-identified loci. These SNPs are associated with the expression of ZNF404 and ANKLE1 in breast tissue. | 28957321 |
| 2017-06-03 12:25:00 | the domains mediating nuclear import and export of Ankle1, were identified. | 27245214 |
| 2017-04-29 12:35:00 | Expression of RCCD1 in whole blood was also suggestively associated with disease risk (p-value: 1.2x10-05), as were expression of ACAP1 (p-value: 1.9x10-05) and LRRC25 (p-value: 5.2x10-05). While genome-wide association studies (GWAS) have implicated RCCD1 and ANKLE1 in breast cancer risk, they have not identified the remaining three genes | 28362817 |
| Type | IDs |
|---|---|
| Synonymous | ANKRD41, LEM3, LEMD6 |
| Gene |
UniProtKB-ID:
ANKL1_HUMAN,
B4DSY8_HUMAN,
B4E124_HUMAN,
A0A499FJM0_HUMAN
UniprotKB:
Q8NAG6,
B4DSY8,
B4E124,
A0A499FJM0
UniParc:
UPI000165D67E,
UPI0003349016,
UPI000013E049,
UPI00017A7A6B,
UPI00017A847F
EMBL:
AK303628,
EU184013,
AK096688,
AK092706,
AK299977,
AC010463
Ensembl:
ENSG00000160117
KO:
hsa:126549
|
| Nucleutide sequences |
EMBL-CDS:
BAC04840.1,
BAC03953.1,
ABW73565.1,
BAG61800.1,
BAG64636.1
Ensembl_TRS:
ENST00000404085,
ENST00000394458
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000384008,
ENSP00000377971
RefSeq:
NP_001265372.2,
NP_001265373.2,
NP_001265374.2,
NP_689576.6
|
| Others |
UniRef100:
UniRef100_A0A0A0MSC6,
UniRef100_B4DSY8,
UniRef100_Q8NAG6
UniRef90:
UniRef90_M0R002,
UniRef90_Q8NAG6,
UniRef90_A0A0A0MSC6
UniRef50:
UniRef50_Q8NAG6,
UniRef50_A0A0A0MSC6
UniGene:
Hs.721610
CCDS:
CCDS12354.3
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 32866453 |
Human ANKLE1 Is a Nuclease Specific for Branched DNA. J Mol Biol Junfang Song , Alasdair D J Freeman , Axel Knebel , Anton Gartner , David M J Lilley |
2020-10-02 | - |
| 31509622 |
Int J Cancer Jianbo Tian , Pingting Ying , Juntao Ke , Ying Zhu , Yang Yang , Yajie Gong , Danyi Zou , Xiating Peng , Nan Yang , Xiaoyang Wang , Shufang Mei , Yuxing Zhang , Changyi Wang , Rong Zhong , Jiang Chang , Xiaoping Miao |
2020-06-15 | - |
| 28957321 |
Identification of breast cancer associated variants that modulate transcription factor binding. PLoS Genet Yunxian Liu , Ninad M Walavalkar , Mikhail G Dozmorov , Stephen S Rich , Mete Civelek , Michael J Guertin |
2017-09-01 | - |
| 28362817 |
Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes associated with breast cancer risk. PLoS Genet Joshua D Hoffman , Rebecca E Graff , Nima C Emami , Caroline G Tai , Michael N Passarelli , Donglei Hu , Scott Huntsman , Dexter Hadley , Lancelote Leong , Arunabha Majumdar , Noah Zaitlen , Elad Ziv , John S Witte |
2017-03-01 | - |
| 27245214 |
BMC Cell Biol. Livija Zlopasa , Andreas Brachner , Roland Foisner |
2016-06-01 | - |
| 24325915 |
Carcinogenesis Kristen S Purrington , Susan Slager , Diana Eccles , Drakoulis Yannoukakos , Peter A Fasching , Penelope Miron , Jane Carpenter , Jenny Chang-Claude , Nicholas G Martin , Grant W Montgomery , Vessela Kristensen , Hoda Anton-Culver , Paul Goodfellow , William J Tapper , Sajjad Rafiq , Susan M Gerty , Lorraine Durcan , Irene Konstantopoulou , Florentia Fostira , Athanassios Vratimos , Paraskevi Apostolou , Irene Konstanta , Vassiliki Kotoula , Sotiris Lakis , Meletios A Dimopoulos , Dimosthenis Skarlos , Dimitrios Pectasides , George Fountzilas , Matthias W Beckmann , Alexander Hein , Matthias Ruebner , Arif B Ekici , Arndt Hartmann , Ruediger Schulz-Wendtland , Stefan P Renner , Wolfgang Janni , Brigitte Rack , Christoph Scholz , Julia Neugebauer , Ulrich Andergassen , Michael P Lux , Lothar Haeberle , Christine Clarke , Nirmala Pathmanathan , Anja Rudolph , Dieter Flesch-Janys , Stefan Nickels , Janet E Olson , James N Ingle , Curtis Olswold , Seth Slettedahl , Jeanette E Eckel-Passow , S Keith Anderson , Daniel W Visscher , Victoria L Cafourek , Hugues Sicotte , Naresh Prodduturi , Elisabete Weiderpass , Leslie Bernstein , Argyrios Ziogas , Jennifer Ivanovich , Graham G Giles , Laura Baglietto , Melissa Southey , Veli-Matti Kosma , Hans-Peter Fischer , GENICA Network , Malcom W R Reed , Simon S Cross , Sandra Deming-Halverson , Martha Shrubsole , Qiuyin Cai , Xiao-Ou Shu , Mary Daly , Joellen Weaver , Eric Ross , Jennifer Klemp , Priyanka Sharma , Diana Torres , Thomas Rüdiger , Heidrun Wölfing , Hans-Ulrich Ulmer , Asta Försti , Thaer Khoury , Shicha Kumar , Robert Pilarski , Charles L Shapiro , Dario Greco , Päivi Heikkilä , Kristiina Aittomäki , Carl Blomqvist , Astrid Irwanto , Jianjun Liu , Vernon Shane Pankratz , Xianshu Wang , Gianluca Severi , Arto Mannermaa , Douglas Easton , Per Hall , Hiltrud Brauch , Angela Cox , Wei Zheng , Andrew K Godwin , Ute Hamann , Christine Ambrosone , Amanda Ewart Toland , Heli Nevanlinna , Celine M Vachon , Fergus J Couch |
2014-05-01 | - |
| 22976474 |
Hum Mol Genet Afshan Siddiq , Fergus J Couch , Gary K Chen , Sara Lindström , Diana Eccles , Robert C Millikan , Kyriaki Michailidou , Daniel O Stram , Lars Beckmann , Suhn Kyong Rhie , Christine B Ambrosone , Kristiina Aittomäki , Pilar Amiano , Carmel Apicella , Australian Breast Cancer Tissue Bank Investigators , Laura Baglietto , Elisa V Bandera , Matthias W Beckmann , Christine D Berg , Leslie Bernstein , Carl Blomqvist , Hiltrud Brauch , Louise Brinton , Quang M Bui , Julie E Buring , Saundra S Buys , Daniele Campa , Jane E Carpenter , Daniel I Chasman , Jenny Chang-Claude , Constance Chen , Françoise Clavel-Chapelon , Angela Cox , Simon S Cross , Kamila Czene , Sandra L Deming , Robert B Diasio , W Ryan Diver , Alison M Dunning , Lorraine Durcan , Arif B Ekici , Peter A Fasching , Familial Breast Cancer Study , Heather Spencer Feigelson , Laura Fejerman , Jonine D Figueroa , Olivia Fletcher , Dieter Flesch-Janys , Mia M Gaudet , GENICA Consortium , Susan M Gerty , Jorge L Rodriguez-Gil , Graham G Giles , Carla H van Gils , Andrew K Godwin , Nikki Graham , Dario Greco , Per Hall , Susan E Hankinson , Arndt Hartmann , Rebecca Hein , Judith Heinz , Robert N Hoover , John L Hopper , Jennifer J Hu , Scott Huntsman , Sue A Ingles , Astrid Irwanto , Claudine Isaacs , Kevin B Jacobs , Esther M John , Christina Justenhoven , Rudolf Kaaks , Laurence N Kolonel , Gerhard A Coetzee , Mark Lathrop , Loic Le Marchand , Adam M Lee , I-Min Lee , Timothy Lesnick , Peter Lichtner , Jianjun Liu , Eiliv Lund , Enes Makalic , Nicholas G Martin , Catriona A McLean , Hanne Meijers-Heijboer , Alfons Meindl , Penelope Miron , Kristine R Monroe , Grant W Montgomery , Bertram Müller-Myhsok , Stefan Nickels , Sarah J Nyante , Curtis Olswold , Kim Overvad , Domenico Palli , Daniel J Park , Julie R Palmer , Harsh Pathak , Julian Peto , Paul Pharoah , Nazneen Rahman , Fernando Rivadeneira , Daniel F Schmidt , Rita K Schmutzler , Susan Slager , Melissa C Southey , Kristen N Stevens , Hans-Peter Sinn , Michael F Press , Eric Ross , Elio Riboli , Paul M Ridker , Fredrick R Schumacher , Gianluca Severi , Isabel Dos Santos Silva , Jennifer Stone , Malin Sund , William J Tapper , Michael J Thun , Ruth C Travis , Clare Turnbull , Andre G Uitterlinden , Quinten Waisfisz , Xianshu Wang , Zhaoming Wang , Joellen Weaver , Rüdiger Schulz-Wendtland , Lynne R Wilkens , David Van Den Berg , Wei Zheng , Regina G Ziegler , Elad Ziv , Heli Nevanlinna , Douglas F Easton , David J Hunter , Brian E Henderson , Stephen J Chanock , Montserrat Garcia-Closas , Peter Kraft , Christopher A Haiman , Celine M Vachon |
2012-12-15 | - |
| 22399800 |
The endonuclease Ankle1 requires its LEM and GIY-YIG motifs for DNA cleavage in vivo. J. Cell. Sci. Andreas Brachner , Juliane Braun , Medini Ghodgaonkar , Dennis Castor , Livija Zlopasa , Veronika Ehrlich , Josef Jiricny , Josef Gotzmann , Siegfried Knasmüller , Roland Foisner |
2012-02-15 | - |
| 20852633 |
Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet Kelly L Bolton , Jonathan Tyrer , Honglin Song , Susan J Ramus , Maria Notaridou , Chris Jones , Tanya Sher , Aleksandra Gentry-Maharaj , Eva Wozniak , Ya-Yu Tsai , Joanne Weidhaas , Daniel Paik , David J Van Den Berg , Daniel O Stram , Celeste Leigh Pearce , Anna H Wu , Wendy Brewster , Hoda Anton-Culver , Argyrios Ziogas , Steven A Narod , Douglas A Levine , Stanley B Kaye , Robert Brown , Jim Paul , James Flanagan , Weiva Sieh , Valerie McGuire , Alice S Whittemore , Ian Campbell , Martin E Gore , Jolanta Lissowska , Hanna P Yang , Krzysztof Medrek , Jacek Gronwald , Jan Lubinski , Anna Jakubowska , Nhu D Le , Linda S Cook , Linda E Kelemen , Angela Brooks-Wilson , Angela Brook-Wilson , Leon F A G Massuger , Lambertus A Kiemeney , Katja K H Aben , Anne M van Altena , Richard Houlston , Ian Tomlinson , Rachel T Palmieri , Patricia G Moorman , Joellen Schildkraut , Edwin S Iversen , Catherine Phelan , Robert A Vierkant , Julie M Cunningham , Ellen L Goode , Brooke L Fridley , Susan Kruger-Kjaer , Jan Blaeker , Estrid Hogdall , Claus Hogdall , Jenny Gross , Beth Y Karlan , Roberta B Ness , Robert P Edwards , Kunle Odunsi , Kirsten B Moyisch , Julie A Baker , Francesmary Modugno , Tuomas Heikkinenen , Ralf Butzow , Heli Nevanlinna , Arto Leminen , Natalia Bogdanova , Natalia Antonenkova , Thilo Doerk , Peter Hillemanns , Matthias Dürst , Ingo Runnebaum , Pamela J Thompson , Michael E Carney , Marc T Goodman , Galina Lurie , Shan Wang-Gohrke , Rebecca Hein , Jenny Chang-Claude , Mary Anne Rossing , Kara L Cushing-Haugen , Jennifer Doherty , Chu Chen , Thorunn Rafnar , Soren Besenbacher , Patrick Sulem , Kari Stefansson , Michael J Birrer , Kathryn L Terry , Dena Hernandez , Daniel W Cramer , Ignace Vergote , Frederic Amant , Diether Lambrechts , Evelyn Despierre , Peter A Fasching , Matthias W Beckmann , Falk C Thiel , Arif B Ekici , Xiaoqing Chen , Australian Ovarian Cancer Study Group , Australian Cancer Study (Ovarian Cancer) , Ovarian Cancer Association Consortium , Sharon E Johnatty , Penelope M Webb , Jonathan Beesley , Stephen Chanock , Montserrat Garcia-Closas , Tom Sellers , Douglas F Easton , Andrew Berchuck , Georgia Chenevix-Trench , Paul D P Pharoah , Simon A Gayther |
2010-10-01 | - |
| 20852631 |
Nat Genet Antonis C Antoniou , Xianshu Wang , Zachary S Fredericksen , Lesley McGuffog , Robert Tarrell , Olga M Sinilnikova , Sue Healey , Jonathan Morrison , Christiana Kartsonaki , Timothy Lesnick , Maya Ghoussaini , Daniel Barrowdale , EMBRACE , Susan Peock , Margaret Cook , Clare Oliver , Debra Frost , Diana Eccles , D Gareth Evans , Ros Eeles , Louise Izatt , Carol Chu , Fiona Douglas , Joan Paterson , Dominique Stoppa-Lyonnet , Claude Houdayer , Sylvie Mazoyer , Sophie Giraud , Christine Lasset , Audrey Remenieras , Olivier Caron , Agnès Hardouin , Pascaline Berthet , GEMO Study Collaborators , Frans B L Hogervorst , Matti A Rookus , Agnes Jager , Ans van den Ouweland , Nicoline Hoogerbrugge , Rob B van der Luijt , Hanne Meijers-Heijboer , Encarna B Gómez GarcÃa , HEBON , Peter Devilee , Maaike P G Vreeswijk , Jan Lubinski , Anna Jakubowska , Jacek Gronwald , Tomasz Huzarski , Tomasz Byrski , Bohdan Górski , Cezary Cybulski , Amanda B Spurdle , Helene Holland , kConFab , David E Goldgar , Esther M John , John L Hopper , Melissa Southey , Saundra S Buys , Mary B Daly , Mary-Beth Terry , Rita K Schmutzler , Barbara Wappenschmidt , Christoph Engel , Alfons Meindl , Sabine Preisler-Adams , Norbert Arnold , Dieter Niederacher , Christian Sutter , Susan M Domchek , Katherine L Nathanson , Timothy Rebbeck , Joanne L Blum , Marion Piedmonte , Gustavo C Rodriguez , Katie Wakeley , John F Boggess , Jack Basil , Stephanie V Blank , Eitan Friedman , Bella Kaufman , Yael Laitman , Roni Milgrom , Irene L Andrulis , Gord Glendon , Hilmi Ozcelik , Tomas Kirchhoff , Joseph Vijai , Mia M Gaudet , David Altshuler , Candace Guiducci , SWE-BRCA , Niklas Loman , Katja Harbst , Johanna Rantala , Hans Ehrencrona , Anne-Marie Gerdes , Mads Thomassen , Lone Sunde , Paolo Peterlongo , Siranoush Manoukian , Bernardo Bonanni , Alessandra Viel , Paolo Radice , Trinidad Caldes , Miguel de la Hoya , Christian F Singer , Anneliese Fink-Retter , Mark H Greene , Phuong L Mai , Jennifer T Loud , Lucia Guidugli , Noralane M Lindor , Thomas V O Hansen , Finn C Nielsen , Ignacio Blanco , Conxi Lazaro , Judy Garber , Susan J Ramus , Simon A Gayther , Catherine Phelan , Stephen Narod , Csilla I Szabo , MOD SQUAD , Javier Benitez , Ana Osorio , Heli Nevanlinna , Tuomas Heikkinen , Maria A Caligo , Mary S Beattie , Ute Hamann , Andrew K Godwin , Marco Montagna , Cinzia Casella , Susan L Neuhausen , Beth Y Karlan , Nadine Tung , Amanda E Toland , Jeffrey Weitzel , Olofunmilayo Olopade , Jacques Simard , Penny Soucy , Wendy S Rubinstein , Adalgeir Arason , Gad Rennert , Nicholas G Martin , Grant W Montgomery , Jenny Chang-Claude , Dieter Flesch-Janys , Hiltrud Brauch , GENICA , Gianluca Severi , Laura Baglietto , Angela Cox , Simon S Cross , Penelope Miron , Sue M Gerty , William Tapper , Drakoulis Yannoukakos , George Fountzilas , Peter A Fasching , Matthias W Beckmann , Isabel Dos Santos Silva , Julian Peto , Diether Lambrechts , Robert Paridaens , Thomas Rüdiger , Asta Försti , Robert Winqvist , Katri Pylkäs , Robert B Diasio , Adam M Lee , Jeanette Eckel-Passow , Celine Vachon , Fiona Blows , Kristy Driver , Alison Dunning , Paul P D Pharoah , Kenneth Offit , V Shane Pankratz , Hakon Hakonarson , Georgia Chenevix-Trench , Douglas F Easton , Fergus J Couch |
2010-10-01 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
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| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
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