| Type | Description |
|---|---|
| Definition | CASP8 and FADD-like apoptosis regulator |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:29:00 | TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP. | 33238518 |
| 2020-05-02 10:09:00 | The data demonstrate a non-redundant function of c-FLIP for the generation of NKp46(+) innate lymphoid cells, which protect T/B lymphocyte-sufficient mice from intestinal inflammation. | 32103006 |
| 2020-03-28 10:39:00 | findings reveal an important role for cFLIP in the regulation of the inflammatory response; specifically show that deficiency of the long isoform cFLIPL promotes complex II formation, driving pyroptosis, and the secretion of IL-1beta in response to LPS alone | 32193329 |
| 2020-01-18 10:58:00 | CFLAR could be considered as a novel candidate to develop effective therapeutic treatment against cerebral I/R injury. | 31387178 |
| 2019-04-13 11:26:00 | Caspase-8 synergizes with the canonical NLRP3 inflammasome pathway to control caspase-1 processing and IL-1beta maturation, providing a regulatory role for caspase-8 in host resistance to in vivo Paracoccidioides brasiliensis infection. | 29099934 |
| Type | IDs |
|---|---|
| Synonymous | 2310024N18Rik, A430105C05Rik, CLARP, Cash, Casper, FLAME, FLAME-1, Flip, Gm9845, I-FLICE, MRIT, c-Flip |
| Gene |
UniProtKB-ID:
CFLAR_MOUSE,
Q5U4G3_MOUSE,
Q812G4_MOUSE
UniprotKB:
O35732,
Q5U4G3,
Q812G4
UniParc:
UPI0000024758,
UPI0000001A69
EMBL:
BC085105,
Y14041,
BC029223,
AC112968,
U97076,
Y14042,
AK143812
Ensembl:
ENSMUSG00000026031
KO:
mmu:12633
|
| Nucleutide sequences |
EMBL-CDS:
CAA74369.1,
AAC53281.1,
CAA74368.1,
BAE25546.1,
AAH85105.1,
AAH29223.1
Ensembl_TRS:
ENSMUST00000114313,
ENSMUST00000069333,
ENSMUST00000114309
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000109952,
ENSMUSP00000109948,
ENSMUSP00000065107
RefSeq:
NP_997536.1,
XP_030100848.1,
XP_011236723.1,
XP_011236722.1,
XP_036012782.1,
NP_001280733.1,
NP_001341985.1,
XP_011236724.1,
XP_011236725.1,
NP_001280734.1,
NP_033935.2,
NP_001276633.1,
XP_006495698.1
|
| Others |
UniRef100:
UniRef100_Q5U4G3,
UniRef100_O35732
UniRef90:
UniRef90_Q5U4G3,
UniRef90_O35732
UniRef50:
UniRef50_O35732,
UniRef50_O15519-2
UniGene:
Mm.336848,
Mm.486313
CCDS:
CCDS14978.1,
CCDS35582.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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