| Type | Description |
|---|---|
| Definition | cyclin-dependent kinase 4 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-20 13:35:00 | The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. | 32701505 |
| 2021-02-06 13:58:00 | CDK4/6 Dependence of Cyclin D1-Driven Parathyroid Neoplasia in Transgenic Mice. | 32877917 |
| 2020-12-19 13:43:00 | Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas. | 32913049 |
| 2019-12-14 12:06:00 | Fkbp5 sequesters Cdk4 within the Hsp90 storage complex and prevents the formation of the cyclin D1-Cdk4 complex, which is a major inhibitor of differentiation. | 30485818 |
| 2019-06-15 12:28:00 | The authors' findings establish a firm molecular link of multiaggressiveness among SCP3, NANOG, cyclin D1, and CDK4/6 and identify CDK4/6 inhibitors as actionable drugs for controlling SCP3(high) immune-refractory cancer. These findings reveal cyclin D1-CDK4/6 inhibition as an effective strategy for controlling SCP3high immune-refractroy cancer. | 29437706 |
| Type | IDs |
|---|---|
| Synonymous | Crk3 |
| Gene |
UniProtKB-ID:
CDK4_MOUSE,
Q545C3_MOUSE
UniprotKB:
P30285,
Q545C3
UniParc:
UPI0000003EF5
EMBL:
BC046336,
X57238,
AK146107,
AK011871,
X65069,
L01640,
BC052694,
AK153465
Ensembl:
ENSMUSG00000006728
KO:
mmu:12567
|
| Nucleutide sequences |
EMBL-CDS:
AAH52694.1,
AAH46336.1,
AAA37646.1,
CAA46202.1,
CAA40514.1,
BAE26906.1,
BAE32016.1,
BAB27890.1
Ensembl_TRS:
ENSMUST00000006911
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000006911
RefSeq:
NP_034000.1,
NP_001341934.1
|
| Others |
UniRef100:
UniRef100_P30285
UniRef90:
UniRef90_P30285
UniRef50:
UniRef50_P11802
UniGene:
Mm.6839
CCDS:
CCDS24226.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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