| Type | Description |
|---|---|
| Definition | response regulator in two-component regulatory system with PhoQ |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 12:10:00 | Facultative intracellular pathogen Salmonella enterica serovar Typhimurium decreases H-NS amounts 16-fold when inside macrophages. This decrease requires both the protease Lon and the DNA-binding virulence regulator PhoP. The decrease in H-NS abundance reduces H-NS binding to foreign DNA, allowing transcription of foreign genes, including those required for intramacrophage survival. | 32209674 |
| 2019-07-06 11:20:00 | Findings indicate that the acetyl phosphate-dependent acetylation of K102 inhibits the phosphorylation of PhoP and decreases the virulence of S. typhimurium, revealing the underlying mechanism of bacterial virulence regulated by primary metabolism. | 30866760 |
| 2019-06-29 11:27:00 | PhoP furthers its activation by promoting Lon-mediated degradation of EIIA(Ntr) at acidic pH. These results suggest that Salmonella ensures robust activation of its virulence system by suspending the activation of PhoP until a sufficient level of active PhoP is present to overcome the inhibitory effect of EIIA(Ntr). | 30967459 |
| 2018-06-02 10:54:00 | These data suggest that when Salmonella experiences mildly acidic pH, the virulence regulator PhoP activation requires the sensor protein PhoQ to detect pH and the Salmonella-specific protein UgtL to amplify the PhoQ response. | 28851823 |
| 2017-09-09 13:01:00 | The Salmonella adaptor ClpS binds to the N terminus of the regulatory protein PhoP, resulting in PhoP degradation by ClpAP. the PhoP-activated protein MgtC protects PhoP from degradation by outcompeting ClpS for binding to PhoP. | 28431231 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
PHOP_SALTY
UniprotKB:
P0DM78
UniParc:
UPI00001319C9
EMBL:
AE006468,
M24424,
M25241
EnsemblGenome:
STM1231
KO:
stm:STM1231
|
| Nucleutide sequences |
EMBL-CDS:
AAA27188.1,
AAA27187.1,
AAL20160.1
EnsemblGenome_TRS:
AAL20160
|
| Protein sequencees |
EnsemblGenome_PRO:
AAL20160
RefSeq:
NP_460201.1
|
| Others |
UniRef100:
UniRef100_Q5PMJ1
UniRef90:
UniRef90_Q8Z7H2
UniRef50:
UniRef50_P23836
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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