| Type | Description |
|---|---|
| Definition | effector protein SifA |
| Date | Results | Publications |
|---|---|---|
| 2016-08-06 11:11:00 | We used a model of SKIP knockout mice to show that this protein mediates the host susceptibility to salmonellosis and to establish that SifA also contributes to Salmonella virulence independently of its interaction with SKIP | 26268777 |
| 2015-10-10 10:58:00 | Authors show that Pleckstrin homology domain-containing protein family member 1 (PLEKHM1), a lysosomal adaptor, is targeted by Salmonella through direct interaction with SifA. | 25500191 |
| 2010-01-25 12:01:00 | Data shoe that the N-terminal domain of SifA is sufficient to interact with the pleckstrin homology domain of SKIP, forming a 1:1 complex with a micromolar dissociation constant. | 19801640 |
| 2010-01-21 00:00:00 | S. Typhimurium sifA was shown to escape the SCVs (S.typhimurium containing vacuoles) into the cytosol of infected dendritic cells (DCs), and was more efficient than S. Typhimurium aroC as a gene delivery vector to DCs. | 15469435 |
| 2010-01-21 00:00:00 | Salmonella typhimurium effector protein SifA is modified by host cell prenylation and S-acylation machinery | 15710609 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
SIFA_SALTY
UniprotKB:
Q56061
UniParc:
UPI0000049ED6
EMBL:
AE006468,
U51867
EnsemblGenome:
STM1224
KO:
stm:STM1224
|
| Nucleutide sequences |
EMBL-CDS:
AAL20153.1,
AAA97467.1
EnsemblGenome_TRS:
AAL20153
|
| Protein sequencees |
EnsemblGenome_PRO:
AAL20153
RefSeq:
NP_460194.1
|
| Others |
UniRef100:
UniRef100_Q56061
UniRef90:
UniRef90_Q56061
UniRef50:
UniRef50_Q56061
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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