| Type | Description |
|---|---|
| Definition | endopeptidase La |
| Date | Results | Publications |
|---|---|---|
| 2020-07-25 12:10:00 | Facultative intracellular pathogen Salmonella enterica serovar Typhimurium decreases H-NS amounts 16-fold when inside macrophages. This decrease requires both the protease Lon and the DNA-binding virulence regulator PhoP. The decrease in H-NS abundance reduces H-NS binding to foreign DNA, allowing transcription of foreign genes, including those required for intramacrophage survival. | 32209674 |
| 2019-12-07 10:49:00 | down-regulation of Salmonella pathogenicity island 1 genes depends on the master regulator HilD, and altering translational fidelity destabilizes HilD protein via enhanced degradation by Lon protease | 30941426 |
| 2019-06-29 11:27:00 | PhoP furthers its activation by promoting Lon-mediated degradation of EIIA(Ntr) at acidic pH. These results suggest that Salmonella ensures robust activation of its virulence system by suspending the activation of PhoP until a sufficient level of active PhoP is present to overcome the inhibitory effect of EIIA(Ntr). | 30967459 |
| 2015-07-25 10:40:00 | Authors show that the ATP-dependent Lon protease plays an important role in regulating the expression of RamA and therefore multidrug resistance via AcrAB-TolC in Salmonella typhimurium. | 24169580 |
| 2010-01-21 00:00:00 | negatively regulates SPI1 transcription through degradation of the HilC and HilD regulator proteins | 15661008 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
Q8ZRB9_SALTY
UniprotKB:
Q8ZRB9
UniParc:
UPI00000CCEC5
EMBL:
AE006468
EnsemblGenome:
STM0450
KO:
stm:STM0450
|
| Nucleutide sequences |
EMBL-CDS:
AAL19405.1
|
| Protein sequencees |
RefSeq:
NP_459446.1
|
| Others |
UniRef100:
UniRef100_A0A3U8P9Y1
UniRef90:
UniRef90_P0A9M1
UniRef50:
UniRef50_P0A9M1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员