| Type | Description |
|---|---|
| Definition | ectonucleoside triphosphate diphosphohydrolase 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-01-19 11:17:00 | NTPDase2 protects from liver fibrosis but Entpd2 deletion does not significantly impact fibrosis | 29134411 |
| 2018-02-10 10:50:00 | NTPDase2 and -3 are ecto-enzymes expressed in the enteric nervous system. Both enzymes confer protection against gut inflammation in experimental colitis and exhibit alterations in Crohn's disease. These observations suggest that purinergic signalling modulated by E-NTPDases governs neuro-immune interactions that are relevant in Crohn's disease. | 28472257 |
| 2017-06-10 11:18:00 | Mesenteric endothelial cells are primed by schistosomiasis to a pro-inflammatory phenotype characterized by an increased expression of NTPDases 2 and 3, favoring ADP accumulation and mononuclear cell adhesion, possibly contributing to mesenteric inflammation and schistosomiasis morbidity via P2Y1 receptor signaling. | 26924460 |
| 2015-12-05 11:48:00 | The analysis of single and double KO mice demonstrated that NTPDase2 and P2Y1 receptors are not required for murine eye formation | 25504514 |
| 2015-09-26 19:08:00 | Authors propose that NTPDase2 has functionality in scavenging mitogenic extracellular nucleoside triphosphates in neurogenic niches of the adult brain, acting as a homeostatic regulator of nucleotide-mediated neural progenitor cell proliferation. | 25205248 |
| Type | IDs |
|---|---|
| Synonymous | Cd39l1, NTPDase2 |
| Gene |
UniProtKB-ID:
ENTP2_MOUSE,
Q921R1_MOUSE
UniprotKB:
O55026,
Q921R1
UniParc:
UPI000002A8E6,
UPI0000022A6B
EMBL:
AK002553,
AY376711,
AF042811,
U91511,
BC011241
Ensembl:
ENSMUSG00000015085
KO:
mmu:12496
|
| Nucleutide sequences |
EMBL-CDS:
BAB22182.1,
AAB81014.1,
AAC24347.1,
AAQ86586.1,
AAH11241.1
Ensembl_TRS:
ENSMUST00000028328
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000028328
RefSeq:
NP_033979.2
|
| Others |
UniRef100:
UniRef100_O55026
UniRef90:
UniRef90_O35795
UniRef50:
UniRef50_O35795
UniGene:
Mm.482100
CCDS:
CCDS15770.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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