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124626 ZPBP2

124626

ZPBP2

zona pellucida binding protein 2

protein-coding

Homo sapiens

基因描述

Type Description
Definition zona pellucida binding protein 2

研究结论

Date Results Publications
2020-04-04 13:03:00 Study of diurnal expression profiles of ZPBP2/Zpbp2, gasdermin B, and ORMDL3/Ormdl3 in human and mouse tissues revealed that Ormdl3 and Zpbp2 were controlled by the circadian clock in a tissue-specific fashion provided the first evidence that disease-associated genes Zpbp2 and Ormdl3 are regulated by circadian rhythms and the Zpbp2 region influences expression of the core clock gene Nr1d1. 31560728
2017-09-09 12:48:00 modest changes (8-13%) in promoter methylation levels of ZPBP2 and GSDMA may cause substantial changes in RNA levels and allelic expression of ZPBP2 and ORMDL3 is mediated by DNA methylation 28241063
2016-12-17 10:58:00 The local genotype influences methylation levels at SLC22A5 and ZPBP2 promoters independently of the asthma status. Further studies are necessary to confirm the relationship between GSDMA-ZPBP2 and SLC22A5 methylation and asthma in females and males separately. 26671913
2015-07-25 10:27:00 The allele T of rs10852936 surrounding the IKZF3-ZPBP2 locus confers risk for early-onset psoriasis. 25620289
2012-11-24 11:18:00 allele-specific transcriptional regulation of genes in the asthma-associated chromosomal region 17q12-q21; rs4795397 influences activity of ZPBP2 promoter in an allele-dependent fashion and leads to nucleosome repositioning on the asthma-associated allele; methylation of exon 1 of ZPBP2 masks the genetic effect on ZPBP2 promoter; ORMDL3 promoter is unmethylated 22271045

名称对应

Type IDs
Synonymous ZPBPL
Gene
UniProtKB-ID: ZPBP2_HUMAN
UniprotKB: Q6X784
UniParc: UPI000000DA1A, UPI00001D79E4
EMBL: BC043152, AK292383, AY251604, AY251603
Ensembl: ENSG00000186075
KO: hsa:124626
Nucleutide sequences
EMBL-CDS: BAF85072.1, AAP83951.1, AAH43152.3, AAP83950.1
Ensembl_TRS: ENST00000348931, ENST00000377940
Protein sequencees
Ensembl_PRO: ENSP00000367174, ENSP00000335384
RefSeq: NP_955353.1, NP_942141.2
Others
UniRef100: UniRef100_Q6X784
UniRef90: UniRef90_Q6X784
UniRef50: UniRef50_Q6X784
UniGene: Hs.367245
CCDS: CCDS11352.1, CCDS11353.2

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