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12385 Ctnna1

12385

Ctnna1

catenin (cadherin associated protein), alpha 1

protein-coding

Mus musculus

基因描述

Type Description
Definition catenin (cadherin associated protein), alpha 1

研究结论

Date Results Publications
2020-01-11 10:41:00 beta-catenin has an TCF/LEF-independent nuclear function that coordinates an extensive network of myogenic genes in cooperation with MyoD; and an alpha-catenin-dependent membrane function that helps control cell-cell interactions 30683662
2019-10-26 10:21:00 alpha-catenin represents a bona fide tumor suppressor for the development of lobular-type breast cancer and as such provides an alternative event to E-cadherin inactivation, adherens junction dysfunction, and subsequent constitutive actomyosin contraction. 29774524
2019-09-07 12:33:00 alphaE-catenin knockout caused heart failure, the upregulation of hypertrophic genes, and the dysregulation of fatty acid metabolism via the transcriptional activity of Yap and beta-catenin. 29923116
2018-09-15 10:25:00 alphaE-catenin is essential for inhibiting nuclear YAP localization and cell proliferation. This function of alphaE-catenin is required for formation of the tooth signalling centre, the enamel knot (EK), which maintains dental mesenchymal condensation and epithelial invagination. alphaE-catenin restricts YAP/TAZ activity to establish a group of non-dividing and specialized cells that constitute a signalling centre. 27405641
2018-04-28 10:24:00 Catna1 functions as a positive regulator of pancreatic islet cell lineage differentiation by repressing the sonic hedgehog pathway. 28793255

名称对应

Type IDs
Synonymous 2010010M04Rik, AA517462, AI988031, Catna1
Gene
UniProtKB-ID: CTNA1_MOUSE, Q545R0_MOUSE
UniprotKB: P26231, Q545R0
UniParc: UPI0000003E89
EMBL: AK159339, X59990, AK004623, AK148496, D90362, BC048163, BC105576
Ensembl: ENSMUSG00000037815
KO: mmu:12385
Nucleutide sequences
EMBL-CDS: AAH48163.1, BAA14376.1, CAA42607.1, BAB23418.1, AAI05577.1, BAE28588.1, BAE35001.1
Ensembl_TRS: ENSMUST00000042345
Protein sequencees
Ensembl_PRO: ENSMUSP00000049007
RefSeq: XP_036016847.1, NP_033948.1, XP_006525611.1, XP_030106159.1
Others
UniRef100: UniRef100_P26231
UniRef90: UniRef90_P26231
UniRef50: UniRef50_P26231
UniGene: Mm.18962
CCDS: CCDS29139.1

全选

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