Nr1i3 - nuclear receptor subfamily 1, group I, member 3-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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12355 Nr1i3

基因描述

Type	Description
Definition	nuclear receptor subfamily 1, group I, member 3

研究结论

Date	Results	Publications
2021-02-13 13:20:00	Activation of the Akt pathway by a constitutive androstane receptor agonist results in beta-catenin activation.	32339513
2020-12-12 13:26:00	Nuclear receptor CAR-ERalpha signaling regulates the estrogen sulfotransferase gene in the liver.	32193417
2020-02-22 11:22:00	CAR contributes an expansive role regulating energy metabolism, significantly impacting glucose and monocarboxylic acid utilization, fatty acid metabolism and lipid homeostasis, through receptor-mediated regulation of several genes in multiple associated pathways.	30336042
2019-08-31 10:47:00	RNA-Seq performed from livers of adult male C57BL/6 mice treated with PXR or CAR agonists identified differentially expressed lncRNAs-protein-coding genes (PCGs) pairs that displayed a high coregulatory pattern by PXR and CAR activation. Study was among the first to demonstrate that lncRNAs are regulated by PXR and CAR activation and that they may be important regulators of PCGs involved in xenobiotic metabolism.	30593543
2019-07-20 11:20:00	new findings in this report link an important role in CAR activation that is dependent upon oxidative stress.	28422158

名称对应

Type	IDs
Synonymous	AA209988, AI551208, CAR, CAR-beta, Care2, ESTM32, MB67
Gene	UniProtKB-ID: NR1I3_MOUSE, Q3UEP1_MOUSE, Q5FW96_MOUSE UniprotKB: O35627, Q3UEP1, Q5FW96 UniParc: UPI00005AC899, UPI00004346CC, UPI000015C213, UPI0000020EE1 EMBL: AF009328, CH466520, AC163497, AC084821, AF009327, BC089541, AK149430, AK133515 Ensembl: ENSMUSG00000005677 KO: mmu:12355
Nucleutide sequences	EMBL-CDS: AAC53350.1, AAC53349.1, EDL39126.1, BAE21697.1, BAE28870.1, AAH89541.1 Ensembl_TRS: ENSMUST00000075469, ENSMUST00000005820, ENSMUST00000155126, ENSMUST00000111328
Protein sequencees	Ensembl_PRO: ENSMUSP00000005820, ENSMUSP00000074915, ENSMUSP00000137683, ENSMUSP00000106960 RefSeq: XP_006496692.1, NP_001229992.1, XP_011237045.1, XP_036012044.1, NP_001229991.1, XP_030100295.1, NP_033933.2, XP_006496691.1
Others	UniRef100: UniRef100_O35627, UniRef100_Q5FW96 UniRef90: UniRef90_O35627 UniRef50: UniRef50_Q14994-8 UniGene: Mm.486506 CCDS: CCDS56654.1, CCDS15480.1

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mRNA

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全选

Pubmed编号	文献信息	发表日期	相关基因
32339513	Activation of the Akt pathway by a constitutive androstane receptor agonist results in Î²-catenin activation. Eur J Pharmacol Andrei A Yarushkin , Mark E Mazin , Yuliya A Pustylnyak , Elena A Prokopyeva , Vladimir O Pustylnyak	2020-07-15	-
32193417	Nuclear receptor CAR-ERÎ± signaling regulates the estrogen sulfotransferase gene in the liver. Sci Rep MyeongJin Yi , Muluneh Fashe , Shingo Arakawa , Rick Moore , Tatsuya Sueyoshi , Masahiko Negishi	2020-03-19	-
31875848	Microbial bile acid metabolites modulate gut RORÎ³⁺Â regulatory T cell homeostasis. Nature Xinyang Song , Ximei Sun , Sungwhan F Oh , Meng Wu , Yanbo Zhang , Wen Zheng , Naama Geva-Zatorsky , Ray Jupp , Diane Mathis , Christophe Benoist , Dennis L Kasper	2020-01-01	-
31095752	Dual Roles of Mammalian Target of Rapamycin in Regulating Liver Injury and Tumorigenesis in Autophagy-Defective Mouse Liver. Hepatology Hong-Min Ni , Xiaojuan Chao , Hua Yang , Fengyan Deng , Shaogui Wang , Qingyun Bai , Hui Qian , Yue Cui , Wei Cui , Yinghong Shi , Wei-Xing Zong , Zhengtao Wang , Li Yang , Wen-Xing Ding	2019-12-01	-
30910785	An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials. Drug Metab Dispos C J Henderson , Y Kapelyukh , N Scheer , A Rode , A W McLaren , A K MacLeod , D Lin , J Wright , L A Stanley , C R Wolf	2019-06-01	-
30573465	Suppression of Hepatic CYP3A4 Expression and Activity by 3-Methylcholanthrene in Humanized PXR-CAR-CYP3A4/3A7 Mice. Drug Metab. Dispos. Michael Crosby , David S Riddick	2019-03-01	-
30593543	Regulation of Hepatic Long Noncoding RNAs by Pregnane X Receptor and Constitutive Androstane Receptor Agonists in Mouse Liver. Drug Metab Dispos Joseph L Dempsey , Julia Yue Cui	2019-03-01	-
30336042	Metabolomic Approaches Reveal the Role of CAR in Energy Metabolism. J Proteome Res Fengming Chen , Denise M Coslo , Tao Chen , Limin Zhang , Yuan Tian , Philip B Smith , Andrew D Patterson , Curtis J Omiecinski	2019-01-04	-
29890134	CAR-mediated repression of Cdkn1a(p21) is accompanied by the Akt activation. Biochem. Biophys. Res. Commun. Andrei A Yarushkin , Mark E Mazin , Anastasia Y Yunusova , Kseniya V Korchagina , Yuliya A Pustylnyak , Elena A Prokopyeva , Vladimir O Pustylnyak	2018-10-02	-
30102401	In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets. Nucleic Acids Res Ben Niu , Denise M Coslo , Alain R Bataille , Istvan Albert , B Franklin Pugh , Curtis J Omiecinski	2018-09-19	-

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