| Type | Description |
|---|---|
| Definition | calpain, small subunit 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-15 11:55:00 | deletion of Capns1 elevated the protein levels of beta-catenin in endothelial cells of Capns1-KO mice and constitutive activity of calpain 2 suppressed beta-catenin protein expression in cultured endothelial cells | 30778623 |
| 2015-12-05 10:31:00 | Mitochondrial calpain-1 disrupts ATP synthase, leading to mitochondrial reactive oxygen species generation, which promotes proinflammatory response and myocardial dysfunction during endotoxemia. | 26246018 |
| 2013-12-21 10:53:00 | Calpain in osteoblasts regulates cell proliferation through its regulation of p27Kip1. Osteoblast-specific capns1 knockout mice developed a high-fat diet-induced excess body weight gain and impaired glucose tolerance. | 22821549 |
| 2012-11-17 10:24:00 | effects of Capn4 deletion may be mediated through prevention of IkappaB degradation and NF-kappaB activation, resulting in inhibition of inflammatory responses. | 22753411 |
| 2011-09-03 10:40:00 | Calpain 4 is essential for the tyrosine phosphorylation of galectin-3, and its ultimate secretion from the cell, and its secretion probably interferes with the production of traction forces. | 21640083 |
| Type | IDs |
|---|---|
| Synonymous | Capa-4, Capa4, Capn4, Cdps, Css1, D7Ertd146e |
| Gene |
UniProtKB-ID:
CPNS1_MOUSE,
A0A0R4IZW8_MOUSE
UniprotKB:
O88456,
A0A0R4IZW8
UniParc:
UPI0000020BC3,
UPI00000297EC
EMBL:
AF139373,
AK132819,
BC090988,
AF058298,
AK028092,
AC164703,
BC018352,
AC149067
Ensembl:
ENSMUSG00000001794
KO:
mmu:12336
|
| Nucleutide sequences |
EMBL-CDS:
BAC25743.1,
AAH18352.1,
AAC97194.1,
AAD38363.2,
AAH90988.1,
BAE21378.1
Ensembl_TRS:
ENSMUST00000126116,
ENSMUST00000001845
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000117951,
ENSMUSP00000001845
RefSeq:
XP_011248722.1,
XP_006539551.1,
NP_033925.2
|
| Others |
UniRef100:
UniRef100_O88456,
UniRef100_A0A0R4IZW8
UniRef90:
UniRef90_P04632
UniRef50:
UniRef50_P04632
UniGene:
Mm.439782
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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